Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer

Table 2 The 2-year estimated overall survival (OS), disease-free survival (DFS), locoregional progress-free survival (LRPF) and distant metastasis-free (DMF) rate of postoperative irradiation with or without of chemotherapy for high-risk oral cavity cancer at the Far Eastern Memorial Hospital (FEMH) compared with selected published series

Selected published Series	No. of postoperative patient	Proportion of OCC	T3 -4	LN involvement ≥2 Positive	Stage III, IV	Resection margin positive or close	ECE	PNI	LVSI/or VEs	Mod- Ality	2-year
		(%)	(%)	(%)	(%)	(%)	(%)	(%)	(%)	(%)	OS (%)	DFS (%)	LR PF (%)	DMF (%)
Eisbruch et al.[3]	133	20	-	-	91	7	48	-	-	OP→ IMRT +C/T	-	-	65¶	-
Studer et al.[15]	28	100	32	57	68	-	-	-	-	OP→ IMRT +/-C/T	83	87	91	95
Chao KS et al.[16]	65	17.6	52	56	86	-	-	-	-	OP→ IMRT	-	-	90	-
Yao M et al.[18]	55	100	56	36	91					OP→ IMRT	68	74	82	89
Gomez DR et al.[19]	35	100	40	38	80	43	36	54	26	OP→ IMRT +/-C/T	74	70	84	85
Chen WC et al., Taiwan[17]	22	100	-	32	100	5	32	-	-	OP→ IMRT +/-C/T	72	64	-	-
FEMH, Taiwan	19	100	68	58	95	52.6	42.1	73.7	68.4	OP→ HT +/-C/T	94	84	92	94

*Value estimated from survival curves. †High-risk OCC: extracapsular spread, Resection-margin positive or close, or more than one adverse factor. ¶ The estimated 2-year LRPF rate belong to OCC only.
Abbreviations:
OCC = oral cavity cancer; LN = Lymph node; ECE = Extracapsular extension; PNI = Perineural involvement; LVSI = Lymphovascular space involvement; VEs = vascular embolisms; OS = overall survival; DFS = disease-free survival; LRPF= locoregional progress-free survival; DMF = distant metastasis-free; OP = operation; RT = External beam radiation therapy; IMRT = intensity-modulated radiation therapy; HT = helical tomotherapy; C/T = chemotherapy; FEMH = Far Eastern Memorial Hospital.

ISSN: 1471-2407