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Table 2 The 2-year estimated overall survival (OS), disease-free survival (DFS), locoregional progress-free survival (LRPF) and distant metastasis-free (DMF) rate of postoperative irradiation with or without of chemotherapy for high-risk oral cavity cancer at the Far Eastern Memorial Hospital (FEMH) compared with selected published series

From: Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer

Selected published Series No. of postoperative patient Proportion of OCC T3 -4 LN involvement ≥2 Positive Stage III, IV Resection margin positive or close ECE PNI LVSI/or VEs Mod- Ality 2-year
   (%) (%) (%) (%) (%) (%) (%) (%) (%) OS (%) DFS (%) LR PF (%) DMF (%)
Eisbruch et al.[3] 133 20 - - 91 7 48 - - OP→ IMRT +C/T - - 65¶ -
Studer et al.[15] 28 100 32 57 68 - - - - OP→ IMRT +/-C/T 83 87 91 95
Chao KS et al.[16] 65 17.6 52 56 86 - - - - OP→ IMRT - - 90 -
Yao M et al.[18] 55 100 56 36 91      OP→ IMRT 68 74 82 89
Gomez DR et al.[19] 35 100 40 38 80 43 36 54 26 OP→ IMRT +/-C/T 74 70 84 85
Chen WC et al., Taiwan[17] 22 100 - 32 100 5 32 - - OP→ IMRT +/-C/T 72 64 - -
FEMH, Taiwan 19 100 68 58 95 52.6 42.1 73.7 68.4 OP→ HT +/-C/T 94 84 92 94
  1. *Value estimated from survival curves. †High-risk OCC: extracapsular spread, Resection-margin positive or close, or more than one adverse factor. ¶ The estimated 2-year LRPF rate belong to OCC only.
  2. Abbreviations:
  3. OCC = oral cavity cancer; LN = Lymph node; ECE = Extracapsular extension; PNI = Perineural involvement; LVSI = Lymphovascular space involvement; VEs = vascular embolisms; OS = overall survival; DFS = disease-free survival; LRPF= locoregional progress-free survival; DMF = distant metastasis-free; OP = operation; RT = External beam radiation therapy; IMRT = intensity-modulated radiation therapy; HT = helical tomotherapy; C/T = chemotherapy; FEMH = Far Eastern Memorial Hospital.