Toxicity of paclitaxel in NSG mice. NSG mice were treated as indicated on 4 consecutive days. The body weight is shown as fraction for each individual mouse at day 5 and at the beginning of the experiment (A). Significant loss of 10% body weight was observed in the groups treated with paclitaxel (black circle) and paclitaxel/ABT-737 (black triangle) compared with control (black rhomb) animals (one way Anova, Dunnett's multiple test p < 0.01). HE staining of liver tissues revealed multiple picnotic cells after combination treatment (E), which were not found in the other 3 groups: control (B), paclitaxel (C) and ABT-737 (D).