Images show changes in volume leakage (V
) in patient 10 non responder to neoadjuvant chemotherapy (Sataloff grade C). Columns show in A and D: anatomic subtraction images; in B and E: corresponding Ve map acquired using measured Arterial Input Function (AIF); and in C and F: corresponding Ve map acquired using theoretical AIF. Images A, B, and C show data before neoadjuvant chemotherapy treatment and images D, F, and G are post-treatment. After treatment, low decreases in Ve median were seen using the measured AIF (-59%) and theoretical AIF (-50%) in agreement with the pathological observation. Note the disagreement with tumour size changes (-100%). To increase visibility of the color encoded Ve pixels the scale was reduced in postchemotherapy images.