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Figure 4 | BMC Cancer

Figure 4

From: Induction of B-cell lymphoma by UVB Radiation in p53 Haploinsufficient Mice

Figure 4

Metastatic behavior of the CD19 + B cell lymphoma. CD19+ UVBL-1 cells were transfected with GFP and injected subcutaneously into the flanks of Rag2-/- mice. Metastasis was analyzed 11, 18 and 27 days post injection. A: Background staining in the lymph nodes of Rag2-/- mice; isotype staining in red; CD19 staining in blue. B: CD19 staining in the lymph nodes of Rag2-/- mice injected with UVBL-1; isotype staining in red; CD19 staining in blue. C: Double staining showing expression of CD19 by GFP positive cells Lymph node metastasis was analyzed 11 days post implantation. D: Background staining in the spleens of Rag2-/- mice. E: CD19 staining in the spleens of Rag2-/- mice injected with UVBL-1. F: Double staining showing expression of CD19 by GFP positive cells. Bone marrow metastasis was analyzed 27 days post injection. G: Background staining in bone marrow of Rag2-/- mice. H: CD19 staining in the spleen of mice injected with UVBL-1. I. Double staining showing expression of CD19 by GFP positive cells. Bone marrow metastasis was analyzed 27 days post injection. All other tissues examined (thymus, lung, live kidney) were negative.

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