Table 1 Cytotoxicity of peptides to various cell lines and TfR expression

Cancer cells

Organ

BT474

Breast

34.5 ± 3.8

8.8 ± 3.3

3.9

99.9 ± 24.9

< 0.05

T47D

Breast

14.1 ± 3.6

4.0 ± 0.2

3.6

101.4 ± 32.4

< 0.05

SK-BR-3

Breast

25.7 ± 0.6

6.5 ± 0.9

4.0

79.7 ± 21.2

< 0.05

MDA-MB-231

Breast

27.0 ± 1.5

7.8 ± 0.8

3.4

98.1 ± 23.9

< 0.05

BT20

Breast

20.0 ± 2.9

4.8 ± 0.4

4.2

91.5 ± 14.6

< 0.05

ZR75-1

Breast

19.4 ± 1.7

9.3 ± 2.6

2.1

46.4 ± 9.0

0.08

SF295

Brain

19.1 ± 2.9

6.3 ± 1.8

3.0

56.9 ± 17.6

0.08

SN19

Brain

21.9 ± 4.0

7.8 ± 0.5

2.8

75.3 ± 10.0

< 0.05

U251

Brain

17.0 ± 1.4

7.0 ± 2.0

2.4

56.3 ± 22.8

0.13

HuCCT-1

Bile duct

17.1 ± 2.8

8.3 ± 2.5

2.0

46.2 ± 4.6

< 0.05

LNCap

Prostate

15.8 ± 1.5

6.2 ± 0.0

2.5

57.8 ± 5.9

< 0.05

COLO587

Pancreas

13.5 ± 1.2

6.4 ± 1.3

2.1

46.4 ± 15.8

0.18

Normal cells

Hepatocyte (HC)

Liver

59.2 ± 5.0

54.7 ± 3.8

1.1

35.5 ± 4.2

Pancreatic epithelical (PE) cell

Pancreas

59.6 ± 7.2

51.2 ± 3.6

1.2

2.8 ± 0.1