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Table 1 HUVEC genes that increase following treatment with VEGF121/rGel for 24 hours, compared to untreated cells

From: Cytotoxicity of VEGF121/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2

Gene
classification
Accession
Number
Symbol Gene Mean fold
change
Cell adhesion H39560 SELE E-selectin (endothelial adhesion molecule 1)a 94.6
  H07071 VCAM Vascular cell adhesion molecule 1 4.9
  AA284668 PLAU Plasminogen activator, urokinase 2.3
Apoptosis AA476272 TNFAIP3 Tumor necrosis factor alpha-induced protein 3a 13.5
  H48706 BIRC3 baculoviral IAP repeat-containing 3 3.3
Transcription regulation T99236 JUNB jun B proto-oncogene 4.9
  W55872 NF-κBIα nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaa 4.8
  AA451716 NF-κB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) 2.3
  H45711 KLF4 Kruppel-like factor 4 2.3
Chemotaxis AA425102 SCYA2 small inducible cytokine A2 (MCP-1)a 20.2
  H62985 SCYA4 small inducible cytokine A4 (MIP-1β) 5.8
  AA040170 SCYA7 small inducible cytokine A7 (MCP-3) 5.5
  T62491 CXCR4 chemokine (C-X-C motif), receptor 4 (fusin) 1.85
Structural organization NM_004856 KNSL5 kinesin-like 5 (mitotic kinesin-like protein 1) 6.4
  AA479199 NID2 nidogen 2 3.1
  AA453105 H2AFL H2A histone family, member L 2.5
Inflammatory response W69211 SCYA11 small inducible cytokine A11 (Cys-Cys) 8.4
  NM_001964 EGR1 (eotaxin) early growth response 1 3.9
  NM_000963 PTGS2 prostaglandin-endoperoxide synthase 2 (COX-2) 3.3
  AA148736 SCD4 syndecan 4 (amphiglycan, ryudocan) 3.2
Signaling W65461 DUSP5 dual specificity phosphatase 5 (MKP-1) 2.7
Metabolic AA011215 SAT spermidine/spermine N1-acetyltransferase 2.1
  1. a Confirmed by RT-PCR at 4 and 24 h posttreatment