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Table 1 HUVEC genes that increase following treatment with VEGF121/rGel for 24 hours, compared to untreated cells

From: Cytotoxicity of VEGF121/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2

Gene

classification

Accession

Number

Symbol

Gene

Mean fold

change

Cell adhesion

H39560

SELE

E-selectin (endothelial adhesion molecule 1)a

94.6

 

H07071

VCAM

Vascular cell adhesion molecule 1

4.9

 

AA284668

PLAU

Plasminogen activator, urokinase

2.3

Apoptosis

AA476272

TNFAIP3

Tumor necrosis factor alpha-induced protein 3a

13.5

 

H48706

BIRC3

baculoviral IAP repeat-containing 3

3.3

Transcription regulation

T99236

JUNB

jun B proto-oncogene

4.9

 

W55872

NF-κBIα

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaa

4.8

 

AA451716

NF-κB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

2.3

 

H45711

KLF4

Kruppel-like factor 4

2.3

Chemotaxis

AA425102

SCYA2

small inducible cytokine A2 (MCP-1)a

20.2

 

H62985

SCYA4

small inducible cytokine A4 (MIP-1β)

5.8

 

AA040170

SCYA7

small inducible cytokine A7 (MCP-3)

5.5

 

T62491

CXCR4

chemokine (C-X-C motif), receptor 4 (fusin)

1.85

Structural organization

NM_004856

KNSL5

kinesin-like 5 (mitotic kinesin-like protein 1)

6.4

 

AA479199

NID2

nidogen 2

3.1

 

AA453105

H2AFL

H2A histone family, member L

2.5

Inflammatory response

W69211

SCYA11

small inducible cytokine A11 (Cys-Cys)

8.4

 

NM_001964

EGR1

(eotaxin) early growth response 1

3.9

 

NM_000963

PTGS2

prostaglandin-endoperoxide synthase 2 (COX-2)

3.3

 

AA148736

SCD4

syndecan 4 (amphiglycan, ryudocan)

3.2

Signaling

W65461

DUSP5

dual specificity phosphatase 5 (MKP-1)

2.7

Metabolic

AA011215

SAT

spermidine/spermine N1-acetyltransferase

2.1

  1. a Confirmed by RT-PCR at 4 and 24 h posttreatment