Table 1 Clinico-pathological characteristics of different subtypes of Castleman's disease as described in previous studies1-10 and the present case
From: Unicentric castleman's disease located in the lower extremity: a case report
Histologic subtype | Predominant occurence | Epidemiology | Morphology | Immuno-histochemistry | Associated diseases | Clinical course | Therapy |
|---|---|---|---|---|---|---|---|
Hyaline vascular | Unicentric | F = M, young adults | Abnormal follicles with shrunken germinal centers consisting of FDC, "onion skinning", vascular ingrowth: "lollipop" formations, interfollicular hypervasculariza-tion | FDC: CD21, CD35, EGFR | Nephrotic syndrome, mixed connective tissue disorder, Hodgkin disease | Benign | Complete resection |
Plasma cell | Multicentric | F = M, young adults | Hyperplastic germical centers, intact mantle zone infiltrated by mature plasma cells, interfollicular plasmacytosis | Plasma cells: CD138 | Elevated IgG4, elevated IL-6; infections: HHV-8, HIV; autoimmune, paraneoplastic and connective tissue diseases | Aggressive | Multimodal approach: radiation, chemo-therapy, and/or surgery |
Mixed cellularity (present case) | Unicentric | F, 37 years | A combination of hyaline vascular and plasma cell type | FDC: CD23, KiM4P; Plasma cells: CD138 | None | Benign | Complete resection |