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Table 2 Disease specific- survival analysis at 24 years follow-up

From: MMP-1 expression has an independent prognostic value in breast cancer

Variable n HR (95%CI) p (univariate) HR (95%CI) p (multivariate)
ER > 10% 118 0.41 (0.24-0.72) 0.0018*   
PR > 10% 118 0.71 (0.40-1.25) 0.2322   
Ki-67 > 15% 117 2.35 (1.34-4.13) 0.0030* 2.01 (1.12-3.59) 0.0186*
Bcl-2 > 25% 118 0.33 (0.18-0.63) 0.0007* 0.45 (0.23-0.86) 0.0158*
Triple-neg 118 2.05 (1.15-3.68) 0.0158*   
Basal-type 118 2.34 (1.20-4.58) 0.0127*   
p53 > 10% 118 1.73 (0.98-3.06) 0.0601   
MMP-1 tumour cells > 70% 118 1.99 (1.12-3.53) 0.0194* 1.81 (1.01-3.22) 0.0438*
MMP-1 fibroblasts > 30% 118 1.35 (0.77-2.39) 0.2948   
  1. HR = Hazard Ratio
  2. P-value less than 0.05 (*) were considered as significant.
  3. Tumour grade was not included in disease specific -survival analysis, because none of grade I patients died of breast cancer.