MMP-1 expression has an independent prognostic value in breast cancer

BMC Cancer

Table 2 Disease specific- survival analysis at 24 years follow-up

Variable	n	HR (95%CI)	p (univariate)	HR (95%CI)	p (multivariate)
ER > 10%	118	0.41 (0.24-0.72)	0.0018*
PR > 10%	118	0.71 (0.40-1.25)	0.2322
Ki-67 > 15%	117	2.35 (1.34-4.13)	0.0030*	2.01 (1.12-3.59)	0.0186*
Bcl-2 > 25%	118	0.33 (0.18-0.63)	0.0007*	0.45 (0.23-0.86)	0.0158*
Triple-neg	118	2.05 (1.15-3.68)	0.0158*
Basal-type	118	2.34 (1.20-4.58)	0.0127*
p53 > 10%	118	1.73 (0.98-3.06)	0.0601
MMP-1 tumour cells > 70%	118	1.99 (1.12-3.53)	0.0194*	1.81 (1.01-3.22)	0.0438*
MMP-1 fibroblasts > 30%	118	1.35 (0.77-2.39)	0.2948

HR = Hazard Ratio
P-value less than 0.05 (*) were considered as significant.
Tumour grade was not included in disease specific -survival analysis, because none of grade I patients died of breast cancer.

ISSN: 1471-2407