|  | Univariate HR (95% CI) | Multivariate HR (95% CI) |
---|---|---|---|
Age | Â | 1.015 (0.985-1.047) | 1.028 (0.995-1.062) |
Sex | Male | 1 (referent) | 1 (referent) |
 | Female | 1.438 (0.733-2.819) | 1.600 (0.799-3.204) |
Stage | Stage I/II | 1 (referent) | 1 (referent) |
 | Stage III | 2.303 (1.163-4.561) | 2.587 (1.267-5.281) |
Differentiation | Well/Moderate | 1 (referent) | 1 (referent) |
 | Poor/Mucinous | 1.210 (0.426-3.435) | 1.347 (0.415-4.375) |
CIMP | CIMP-low/negative | 1 (referent) | 1 (referent) |
 | CIMP-high | 0.523 (0.160-1.710) | 0.806 (0.207-3.136) |
MSI | MSI-low/MSS | 1 (referent) | 1 (referent) |
 | MSI-high | 0.394 (0.139-1.118) | 0.485 (0.139-1.701) |
BRAF mutation | No | 1 (referent) | 1 (referent) |
 | Yes | No recurrence | No recurrence |
KRAS mutation | No | 1 (referent) | 1 (referent) |
 | Yes | 1.096 (0.542-2.214) | 1.185 (0.568-2.471) |
MGMT methylation | No | 1 (referent) | 1 (referent) |
 | Yes | 0.667 (0.311-1.429) | 0.703 (0.304-1.628) |