Table 3 Concentrations of urinary steroids in the PTC men and control
Steroids | Concentrationa (mean ± SD) | P-value | |
|---|---|---|---|
Controls (n = 20) | PTC (n = 16) | Controls : PTC | |
Androgens | |||
Dihydrotestosterone | 91.39 ± 62.43 | 132.14 ± 92.41 | NSb |
Epidihydrotestosterone | 20.74 ± 16.54 | 28.45 ± 14.21 | NS |
Dehydroepiandrosterone | 144.93 ± 58.60 | 180.74 ± 85.79 | NS |
Testosterone | 101.16 ± 89.00 | 271.30 ± 270.50 | NS |
Epitestosterone | 181.57 ± 93.89 | 177.67 ± 111.44 | NS |
5α-androstan-3α,17β-diol | 381.95 ± 183.28 | 320.57 ± 198.42 | NS |
5α-androstan-3β,17β-diol | 3.70 ± 3.66 | 83.37 ± 99.92 | NS |
5β-androstan-3α,17β-diol | 432.61 ± 362.77 | 607.93 ± 1056.85 | NS |
5β-androstan-3α,17α-diol | 55.09 ± 46.59 | 109.91 ± 153.06 | NS |
5β-androstan-3β,17α-diol | NDc | 4.92 (1) | NCd |
5α-androstan-3β,17α-diol | 31.72 ± 39.33 | 54.92 ± 80.93 | NS |
5α-androstan-3α,17α-diol | 31.13 ± 28.59 | 40.00 ± 63.40 | NS |
5β-androstan-3β,17β-diol | 2.51 (1) | ND | NC |
Androstenedione | 40.66 ± 21.23 | 92.10 ± 51.74 | < 0.002 |
Androstenediol | 28.68 ± 12.20 | 82.31 ± 38.09 | < 0.00005 |
Androsterone | 10087.69 ± 4603.39 | 26110.67 ± 11663.35 | < 0.00006 |
Etiocholanolone | 8256.47 ± 3997.97 | 24745.49 ± 16868.98 | < 0.002 |
11-keto-androsterone + 11-keto-etiocholanolone | 531.90 ± 598.85 | 1660.94 ± 1191.92 | < 0.003 |
11β-hydroxyandrosterone | 4009.02 ± 2754.69 | 7037.26 ± 4372.55 | < 0.02 |
11β-hydroxyetiocholanolone | 1295.60 ± 1325.27 | 2087.71 ± 1610.32 | NS |
5β-dihydrotestosterone | 3.01 ± 1.85 | 17.67 ± 20.67 | < 0.02 |
16α-hydroxy-DHEA | 79.37 ± 43.01 | 186.33 ± 63.29 | < 0.000005 |
Epiandrosterone | 24.21 ± 10.91 | 46.90 ± 33.66 | < 0.02 |
5α-Androstanedione | 11.29 (1) | 24.39 (1) | NC |
Estrogens | |||
Estrone | 39.69 ± 12.89 | 60.18 ± 29.20 | < 0.02 |
17β-estradiol | 12.91 ± 12.56 | 15.05 ± 10.68 | NS |
Estriol | 24.62 ± 11.84 | 44.79 ± 31.46 | < 0.03 |
2-hydroxyestrone | 50.27 ± 25.50 | 91.83 ± 55.12 | < 0.02 |
2-hydroxy-17β-estradiol | 195.56 ± 113.59 | 64.98 ± 38.05 | < 0.00007 |
4-hydroxyestrone | 51.38 ± 26.59 | 59.70 ± 24.78 | NS |
4-hydroxy-17β-estradiol | 18.29 ± 7.63 | 42.05 ± 13.14 | < 0.00009 |
2-methoxyestrone | 22.78 ± 13.07 | 42.46 ± 20.94 | < 0.006 |
2-methoxy-17β-estradiol | 19.41 ± 9.13 | 27.37 ± 14.25 | NS |
4-methoxyestrone | 17.78 ± 7.24 | 34.29 ± 16.50 | < 0.003 |
4-methoxy-17β-estradiol | 19.00 ± 9.90 | 28.78 ± 11.78 | < 0.03 |
17-epiestriol | 42.81 (1) | 49.14 ± 5.76 (2) | NC |
16-epiestriol | 28.28 ± 19.49 | 34.70 ± 16.18 | NS |
17α-estradiol | 0.92 (1) | ND | NC |
2-hydroxyestriol | 0.57 ± 0.77 | 40.82 ± 69.05 | NS |
16-keto-17β-estradiol + 16α-hydroxyestrone | 9.99 ± 4.63 | 22.93 ± 10.98 | < 0.0003 |
Corticoids | |||
Cortisol | 183.91 ± 160.81 | 487.21 ± 482.28 | < 0.03 |
Allodihydrocortisol | 38.21 ± 28.01 | 17.59 ± 8.64 | < 0.005 |
Corticosterone | 33.47 ± 32.89 | 56.57 ± 91.42 | NS |
Allodihydrocorticosterone | 22.53 ± 10.10 | 29.87 ± 13.54 | NS |
Dihydrodeoxycorticosterone | 32.30 ± 37.87 | 134.38 ± 105.38 | < 0.02 |
11-deoxycorticosterone | 28.74 ± 15.27 | 28.78 ± 13.55 | NS |
11-deoxycortisol | 37.14 ± 16.35 | 32.66 ± 15.58 | NS |
Cortisone | 511.43 ± 377.83 | 1580.13 ± 1320.58 | < 0.006 |
Allotetrahydrocortisol | 9510.49 ± 4735.51 | 20666.67 ± 12334.24 | < 0.003 |
21-deoxycortisol | 63.27 ± 29.68 | 88.63 ± 45.03 | NS |
11-dehydrocorticosterone | 110.59 ± 105.33 | 148.87 ± 147.64 | NS |
Tetrahydrodeoxycortisol | 405.48 ± 214.37 | 756.82 ± 539.85 | < 0.03 |
Tetrahydrocortisone | 11055.45 ± 5289.49 | 18809.78 ± 11894.93 | < 0.03 |
Tetrahydrocortisol | 6091.23 ± 2812.78 | 16371.31 ± 10629.87 | < 0.002 |
Tetrahydrodeoxycorticosterone | 24.76 ± 15.31 | 37.50 ± 24.52 | NS |
Tetrahydrocorticosterone | 433.03 ± 604.84 | 659.73 ± 380.95 | NS |
11-dehydrotetrahydrocorticosterone | 993.99 ± 1013.47 | 1127.02 ± 618.49 | NS |
α-cortolone | 4030.85 ± 1778.81 | 6992.04 ± 3748.34 | < 0.009 |
β-cortolone | 2284.12 ± 1041.75 | 3306.24 ± 1662.55 | < 0.05 |
20α-dihydrocortisone | 252.58 ± 107.63 | 431.88 ± 202.66 | < 0.005 |
α-cortol | 838.32 ± 319.86 | 1180.62 ± 550.93 | < 0.04 |
β-cortol | 2181.33 ± 886.33 | 3316.76 ± 1830.36 | < 0.04 |
20α-dihydrocortisol | 87.90 ± 57.63 | 188.16 ± 129.88 | < 0.01 |
Progestins | |||
Pregnenolone | 27.08 ± 13.26 | 41.82 ± 15.30 | < 0.02 |
Progesterone | 22.47 ± 11.45 (2) | 47.85 ± 10.86 (3) | NC |
5β-dihydroprogesterone | 7.90 ± 7.77 | 11.18 | NS |
5α-dihydroprogesterone | 24.37 ± 11.29 | 28.45 ± 35.05 | NS |
20α-hydroprogesterone | 35.96 ± 24.53 | 76.35 ± 54.00 | < 0.01 |
Epipregnanolone | 13.87 ± 8.23 | 16.85 ± 6.83 | NS |
Pregnanolone | 251.57 ± 121.38 | 559.35 ± 835.31 | NS |
Allopregnanolone | 55.53 ± 25.97 | 92.13 ± 129.62 | NS |
Isopregnanolone | 32.57 ± 11.39 | 47.07 ± 24.81 | NS |
Pregnanediol | 1896.17 ± 1077.27 | 5669.51 ± 10408.32 | NS |
Pregnanetriol | 2704.00 ± 1146.97 | 3975.05 ± 1957.07 | < 0.04 |
17α-hydroxypregnenolone | 39.84 ± 22.13 | 58.70 ± 38.95 | NS |
17α-hydroxyprogesterone | 15.19 (1) | 39.82 ± 19.99 | NC |
11β-hydroxyprogesterone | 818.94 ± 373.38 | 2518.86 ± 1739.51 | < 0.002 |
Sterols | |||
Cholesterol | 2028.74 ± 1781.46 | 3851.26 ± 2743.30 | < 0.04 |
Desmosterol | 216.36 ± 88.55 | 421.52 ± 622.80 | NS |
Lanosterol | 58.32 ± 73.89 | 43.89 ± 30.30 | NS |
20α-hydroxycholesterol | 49.98 (1) | 85.15 (1) | NC |
24S-hydroxycholesterol | 111.65 ± 207.00 | 27.96 ± 15.91 | NS |