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Table 2 Concentrations of urinary steroids in post-menopausal PTC women and control

From: Metabolic alteration of urinary steroids in pre- and post-menopausal women, and men with papillary thyroid carcinoma

Steroids

Concentrationa (mean ± SD)

P-value

 

Controls

(n = 16)

PTC

(n = 19)

Controls : PTC

Androgens

   

Dihydrotestosterone

71.99 ± 45.10

91.87 ± 57.97

NSb

Epidihydrotestosterone

38.16 ± 27.60

32.35 ± 58.50

NS

Dehydroepiandrosterone

165.46 ± 91.64

194.37 ± 109.70

NS

Testosterone

102.07 ± 64.62

196.74 ± 232.37

NS

Epitestosterone

92.02 ± 69.39

91.08 ± 60.77

NSb

5α-androstan-3α,17β-diol

87.09 ± 64.60

112.99 ± 94.87

NS

5α-androstan-3β,17β-diol

4.26 (1)

NDc

NCd

5β-androstan-3α,17β-diol

99.98 ± 74.50

109.73 ± 90.40

NS

5β-androstan-3α,17α-diol

67.53 ± 62.11

61.33 ± 68.37

NS

5β-androstan-3β,17α-diol

14.33 ± 13.01 (2)

9.58 ± 7.20 (4)

NC

5α-androstan-3β,17α-diol

22.27 ± 20.57 (2)

34.51 ± 28.74 (4)

NC

5α-androstan-3α,17α-diol

43.24 ± 52.23

37.50 ± 24.00

NS

5β-androstan-3β,17β-diol

ND

18.10 (1)

NC

Androstenedione

110.21 ± 88.05

112.78 ± 59.83

NS

Androstenediol

54.27 ± 26.28

61.30 ± 13.63

NS

Androsterone

4464.11 ± 1786.06

14974.73 ± 17229.72

< 0.02

Etiocholanolone

4850.22 ± 2075.09

13920.59 ± 15821.56

< 0.03

11-keto-androsterone +

11-keto-etiocholanolone

580.33 ± 297.69

1727.55 ± 2045.94

< 0.03

11β-hydroxyandrosterone

4499.84 ± 2455.83

5488.85 ± 4203.96

NS

11β-hydroxyetiocholanolone

1462.44 ± 1071.41

2629.38 ± 2439.84

NS

5β-dihydrotestosterone

4.79 ± 1.61

21.03 ± 9.54

< 0.00003

16α-hydroxy-DHEA

228.48 ± 172.71

271.17 ± 127.46

NS

Epiandrosterone

60.19 ± 61.75

70.25 ± 35.51

NS

5α-Androstanedione

72.20 ± 83.17 (4)

60.13 ± 24.16 (13)

NC

Estrogens

   

Estrone

163.00 ± 176.41 (6)

63.72 ± 47.10 (17)

NC

17β-estradiol

14.24 ± 14.24 (4)

21.84 ± 19.84 (7)

NC

Estriol

56.96 ± 65.77 (6)

60.11 ± 57.72 (17)

NC

2-hydroxyestrone

306.99 ± 99.92 (5)

50.92 ± 30.20 (18)

NC

2-hydroxy-17β-estradiol

131.39 ± 166.91 (6)

168.07 ± 372.40 (17)

NC

4-hydroxyestrone

76.21 ± 15.24 (4)

42.27 ± 49.44 (15)

NC

4-hydroxy-17β-estradiol

33.90 ± 13.10 (4)

44.94 ± 23.08 (16)

NC

2-methoxyestrone

69.67 ± 77.40 (6)

101.47 ± 68.85 (7)

NC

2-methoxy-17β-estradiol

24.53 ± 11.18 (3)

60.09 ± 29.12 (7)

NC

4-methoxyestrone

32.32 (1)

85.60 ± 41.64 (15)

NC

4-methoxy-17β-estradiol

66.69 ± 75.09 (4)

55.39 ± 11.16 (4)

NC

17-epiestriol

254.59 (1)

94.42 ± 44.07 (8)

NC

16-epiestriol

74.15 ± 85.83 (6)

119.59 ± 63.08 (6)

NC

17α-estradiol

ND

ND

NC

2-hydroxyestriol

ND

90.89 ± 102.52 (5)

NC

16-keto-17β-estradiol +

16α-hydroxyestrone

28.01 ± 33.72 (6)

46.10 ± 24.21 (18)

NC

Corticoids

   

Cortisol

235.02 ± 205.57

561.28 ± 345.19

NS

Allodihydrocortisol

71.42 ± 64.96

61.67 ± 84.03

NS

Corticosterone

20.74 ± 5.63

100.83 ± 85.62

< 0.02

Allodihydrocorticosterone

53.16 ± 46.48

66.19 ± 38.41

NS

Dihydrodeoxycorticosterone

20.41 ± 15.52

162.62 ± 155.03

< 0.02

11-deoxycorticosterone

101.66 ± 97.56

61.76 ± 29.06

NS

11-deoxycortisol

101.54 ± 102.04

45.92 ± 22.60

NS

Cortisone

980.80 ± 750.48

2205.39 ± 2667.76

NS

Allotetrahydrocortisol

9613.87 ± 6293.12

17105.92 ± 16369.40

NS

21-deoxycortisol

86.96 ± 32.86

97.31 ± 54.06

NS

11-dehydrocorticosterone

124.14 ± 75.34

194.61 ± 298.04

NS

Tetrahydrodeoxycortisol

794.79 ± 305.00

818.38 ± 581.02

NS

Tetrahydrocortisone

17811.52 ± 12271.25

16114.72 ± 12222.84

NS

Tetrahydrocortisol

8640.16 ± 4558.83

16040.33 ± 12750.63

< 0.05

Tetrahydrodeoxycorticosterone

56.16 ± 73.09

43.58 ± 61.64

NS

Tetrahydrocorticosterone

389.66 ± 207.67

780.31 ± 575.27

< 0.02

11-dehydrotetrahydrocorticosterone

877.74 ± 538.13

1445.62 ± 1602.49

NS

α-cortolone

4888.98 ± 2535.86

29149.71 ± 97516.67

NS

β-cortolone

2589.95 ± 927.40

5524.05 ± 11016.02

NS

20α-dihydrocortisone

375.30 ± 192.08

1766.88 ± 5192.38

NS

α-cortol

944.46 ± 362.03

5294.32 ± 17534.68

NS

β-cortol

2299.34 ± 908.51

8550.42 ± 23540.39

NS

20α-dihydrocortisol

172.51 ± 127.47

786.04 ± 2141.06

NS

Progestins

   

Pregnenolone

66.45 ± 68.65

108.91 ± 65.30

NS

Progesterone

ND

47.86 (1)

NC

5β-dihydroprogesterone

13.35 ± 9.78

ND

NC

5α-dihydroprogesterone

38.87 ± 28.09 (2)

24.96 ± 37.35

NC

20α-hydroprogesterone

121.40 ± 105.37 (3)

276.33 ± 450.77

NC

Epipregnanolone

63.07 ± 63.10

37.64 ± 22.54

NS

Pregnanolone

652.71 ± 1018.03

489.54 ± 1157.06

NS

Allopregnanolone

147.26 ± 129.01

109.29 ± 187.61

NS

Isopregnanolone

60.44 ± 5.17 (3)

73.12 ± 43.22

NC

Pregnanediol

6959.54 ± 12541.46

3635.06 ± 9400.59

NS

Pregnanetriol

1559.68 ± 1314.30

2612.22 ± 3133.33

NS

17α-hydroxypregnenolone

85.37 ± 85.75

106.24 ± 57.67

NS

17α-hydroxyprogesterone

ND

133.63 ± 84.38

NC

11β-hydroxyprogesterone

1204.77 ± 516.99

6580.30 ± 17763.59

NS

Sterols

   

Cholesterol

5103.58 ± 3075.92 (6)

5002.90 ± 3033.29

NC

Desmosterol

197.65 ± 67.86 (2)

ND

NC

Lanosterol

102.03 ± 125.18 (4)

32.83 ± 20.51 (3)

NC

20α-hydroxycholesterol

ND

86.56 ± 4.77 (2)

NC

24S-hydroxycholesterol

116.58 ± 101.37 (4)

54.63 ± 26.17 (7)

NC

  1. The number in the parentheses is the number of subject detected corresponding steroid.
  2. aConcentrations are expressed as ng/g of creatinine (mean ± SD).
  3. bNS, not significant.
  4. cND, not detected.
  5. dNC, not comparable.