Steroids | Concentrationa (mean ± SD) | P-value | |
---|---|---|---|
Controls (n = 16) | PTC (n = 19) | Controls : PTC | |
Androgens | |||
Dihydrotestosterone | 71.99 ± 45.10 | 91.87 ± 57.97 | NSb |
Epidihydrotestosterone | 38.16 ± 27.60 | 32.35 ± 58.50 | NS |
Dehydroepiandrosterone | 165.46 ± 91.64 | 194.37 ± 109.70 | NS |
Testosterone | 102.07 ± 64.62 | 196.74 ± 232.37 | NS |
Epitestosterone | 92.02 ± 69.39 | 91.08 ± 60.77 | NSb |
5α-androstan-3α,17β-diol | 87.09 ± 64.60 | 112.99 ± 94.87 | NS |
5α-androstan-3β,17β-diol | 4.26 (1) | NDc | NCd |
5β-androstan-3α,17β-diol | 99.98 ± 74.50 | 109.73 ± 90.40 | NS |
5β-androstan-3α,17α-diol | 67.53 ± 62.11 | 61.33 ± 68.37 | NS |
5β-androstan-3β,17α-diol | 14.33 ± 13.01 (2) | 9.58 ± 7.20 (4) | NC |
5α-androstan-3β,17α-diol | 22.27 ± 20.57 (2) | 34.51 ± 28.74 (4) | NC |
5α-androstan-3α,17α-diol | 43.24 ± 52.23 | 37.50 ± 24.00 | NS |
5β-androstan-3β,17β-diol | ND | 18.10 (1) | NC |
Androstenedione | 110.21 ± 88.05 | 112.78 ± 59.83 | NS |
Androstenediol | 54.27 ± 26.28 | 61.30 ± 13.63 | NS |
Androsterone | 4464.11 ± 1786.06 | 14974.73 ± 17229.72 | < 0.02 |
Etiocholanolone | 4850.22 ± 2075.09 | 13920.59 ± 15821.56 | < 0.03 |
11-keto-androsterone + 11-keto-etiocholanolone | 580.33 ± 297.69 | 1727.55 ± 2045.94 | < 0.03 |
11β-hydroxyandrosterone | 4499.84 ± 2455.83 | 5488.85 ± 4203.96 | NS |
11β-hydroxyetiocholanolone | 1462.44 ± 1071.41 | 2629.38 ± 2439.84 | NS |
5β-dihydrotestosterone | 4.79 ± 1.61 | 21.03 ± 9.54 | < 0.00003 |
16α-hydroxy-DHEA | 228.48 ± 172.71 | 271.17 ± 127.46 | NS |
Epiandrosterone | 60.19 ± 61.75 | 70.25 ± 35.51 | NS |
5α-Androstanedione | 72.20 ± 83.17 (4) | 60.13 ± 24.16 (13) | NC |
Estrogens | |||
Estrone | 163.00 ± 176.41 (6) | 63.72 ± 47.10 (17) | NC |
17β-estradiol | 14.24 ± 14.24 (4) | 21.84 ± 19.84 (7) | NC |
Estriol | 56.96 ± 65.77 (6) | 60.11 ± 57.72 (17) | NC |
2-hydroxyestrone | 306.99 ± 99.92 (5) | 50.92 ± 30.20 (18) | NC |
2-hydroxy-17β-estradiol | 131.39 ± 166.91 (6) | 168.07 ± 372.40 (17) | NC |
4-hydroxyestrone | 76.21 ± 15.24 (4) | 42.27 ± 49.44 (15) | NC |
4-hydroxy-17β-estradiol | 33.90 ± 13.10 (4) | 44.94 ± 23.08 (16) | NC |
2-methoxyestrone | 69.67 ± 77.40 (6) | 101.47 ± 68.85 (7) | NC |
2-methoxy-17β-estradiol | 24.53 ± 11.18 (3) | 60.09 ± 29.12 (7) | NC |
4-methoxyestrone | 32.32 (1) | 85.60 ± 41.64 (15) | NC |
4-methoxy-17β-estradiol | 66.69 ± 75.09 (4) | 55.39 ± 11.16 (4) | NC |
17-epiestriol | 254.59 (1) | 94.42 ± 44.07 (8) | NC |
16-epiestriol | 74.15 ± 85.83 (6) | 119.59 ± 63.08 (6) | NC |
17α-estradiol | ND | ND | NC |
2-hydroxyestriol | ND | 90.89 ± 102.52 (5) | NC |
16-keto-17β-estradiol + 16α-hydroxyestrone | 28.01 ± 33.72 (6) | 46.10 ± 24.21 (18) | NC |
Corticoids | |||
Cortisol | 235.02 ± 205.57 | 561.28 ± 345.19 | NS |
Allodihydrocortisol | 71.42 ± 64.96 | 61.67 ± 84.03 | NS |
Corticosterone | 20.74 ± 5.63 | 100.83 ± 85.62 | < 0.02 |
Allodihydrocorticosterone | 53.16 ± 46.48 | 66.19 ± 38.41 | NS |
Dihydrodeoxycorticosterone | 20.41 ± 15.52 | 162.62 ± 155.03 | < 0.02 |
11-deoxycorticosterone | 101.66 ± 97.56 | 61.76 ± 29.06 | NS |
11-deoxycortisol | 101.54 ± 102.04 | 45.92 ± 22.60 | NS |
Cortisone | 980.80 ± 750.48 | 2205.39 ± 2667.76 | NS |
Allotetrahydrocortisol | 9613.87 ± 6293.12 | 17105.92 ± 16369.40 | NS |
21-deoxycortisol | 86.96 ± 32.86 | 97.31 ± 54.06 | NS |
11-dehydrocorticosterone | 124.14 ± 75.34 | 194.61 ± 298.04 | NS |
Tetrahydrodeoxycortisol | 794.79 ± 305.00 | 818.38 ± 581.02 | NS |
Tetrahydrocortisone | 17811.52 ± 12271.25 | 16114.72 ± 12222.84 | NS |
Tetrahydrocortisol | 8640.16 ± 4558.83 | 16040.33 ± 12750.63 | < 0.05 |
Tetrahydrodeoxycorticosterone | 56.16 ± 73.09 | 43.58 ± 61.64 | NS |
Tetrahydrocorticosterone | 389.66 ± 207.67 | 780.31 ± 575.27 | < 0.02 |
11-dehydrotetrahydrocorticosterone | 877.74 ± 538.13 | 1445.62 ± 1602.49 | NS |
α-cortolone | 4888.98 ± 2535.86 | 29149.71 ± 97516.67 | NS |
β-cortolone | 2589.95 ± 927.40 | 5524.05 ± 11016.02 | NS |
20α-dihydrocortisone | 375.30 ± 192.08 | 1766.88 ± 5192.38 | NS |
α-cortol | 944.46 ± 362.03 | 5294.32 ± 17534.68 | NS |
β-cortol | 2299.34 ± 908.51 | 8550.42 ± 23540.39 | NS |
20α-dihydrocortisol | 172.51 ± 127.47 | 786.04 ± 2141.06 | NS |
Progestins | |||
Pregnenolone | 66.45 ± 68.65 | 108.91 ± 65.30 | NS |
Progesterone | ND | 47.86 (1) | NC |
5β-dihydroprogesterone | 13.35 ± 9.78 | ND | NC |
5α-dihydroprogesterone | 38.87 ± 28.09 (2) | 24.96 ± 37.35 | NC |
20α-hydroprogesterone | 121.40 ± 105.37 (3) | 276.33 ± 450.77 | NC |
Epipregnanolone | 63.07 ± 63.10 | 37.64 ± 22.54 | NS |
Pregnanolone | 652.71 ± 1018.03 | 489.54 ± 1157.06 | NS |
Allopregnanolone | 147.26 ± 129.01 | 109.29 ± 187.61 | NS |
Isopregnanolone | 60.44 ± 5.17 (3) | 73.12 ± 43.22 | NC |
Pregnanediol | 6959.54 ± 12541.46 | 3635.06 ± 9400.59 | NS |
Pregnanetriol | 1559.68 ± 1314.30 | 2612.22 ± 3133.33 | NS |
17α-hydroxypregnenolone | 85.37 ± 85.75 | 106.24 ± 57.67 | NS |
17α-hydroxyprogesterone | ND | 133.63 ± 84.38 | NC |
11β-hydroxyprogesterone | 1204.77 ± 516.99 | 6580.30 ± 17763.59 | NS |
Sterols | |||
Cholesterol | 5103.58 ± 3075.92 (6) | 5002.90 ± 3033.29 | NC |
Desmosterol | 197.65 ± 67.86 (2) | ND | NC |
Lanosterol | 102.03 ± 125.18 (4) | 32.83 ± 20.51 (3) | NC |
20α-hydroxycholesterol | ND | 86.56 ± 4.77 (2) | NC |
24S-hydroxycholesterol | 116.58 ± 101.37 (4) | 54.63 ± 26.17 (7) | NC |