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Table 1 Concentrations of urinary steroids in pre-menopausal PTC women and control

From: Metabolic alteration of urinary steroids in pre- and post-menopausal women, and men with papillary thyroid carcinoma

Steroids

Concentrationa (mean ± SD)

P-value

 

Controls

(n = 24)

PTC

(n = 21)

Controls : PTC

Androgens

   

Dihydrotestosterone

65.79 ± 47.43

118.67 ± 61.89

< 0.005

Epidihydrotestosterone

20.21 ± 16.70

44.85 ± 18.85

< 0.0007

Dehydroepiandrosterone

151.34 ± 84.40

216.29 ± 93.00

< 0.02

Testosterone

64.73 ± 45.54

116.60 ± 24.77

< 0.03

Epitestosterone

82.61 ± 49.75

109.66 ± 42.13

NSb

5α-androstan-3α,17β-diol

137.28 ± 90.96

202.60 ± 259.73

NS

5α-androstan-3β,17β-diol

20.00 ± 11.75 (3)

42.54 (1)

NCc

5β-androstan-3α,17β-diol

204.52 ± 149.53

248.07 ± 336.60

NS

5β-androstan-3α,17α-diol

70.50 ± 49.49

107.26 ± 105.68

NS

5β-androstan-3β,17α-diol

5.42 ± 1.69 (4)

6.30 ± 1.45 (3)

NC

5α-androstan-3β,17α-diol

21.17 ± 14.55

41.20 ± 28.43

NS

5α-androstan-3α,17α-diol

33.64 ± 26.33

53.18 ± 41.56

NS

5β-androstan-3β,17β-diol

8.75 (1)

36.84 ± 53.75 (4)

NC

Androstenedione

59.17 ± 50.56

96.93 ± 39.56

< 0.01

Androstenediol

51.71 ± 31.61

96.27 ± 33.98

< 0.0002

Androsterone

7826.70 ± 5459.40

24675.61 ± 23074.97

< 0.004

Etiocholanolone

7074.80 ± 4371.84

21993.33 ± 14558.44

< 0.0002

11-keto-androsterone +

11-keto-etiocholanolone

439.95 ± 320.79

2048.15 ± 1749.63

< 0.0005

11β-hydroxyandrosterone

2413.61 ± 1411.53

5197.95 ± 4501.89

< 0.01

11β-hydroxyetiocholanolone

1185.01 ± 873.09

2598.36 ± 1740.91

< 0.003

5β-dihydrotestosterone

3.97 ± 2.92

21.71 ± 9.26

< 0.00008

16α-hydroxy-DHEA

127.76 ± 67.50

285.48 ± 147.21

< 0.0002

Epiandrosterone

33.26 ± 26.59

49.45 ± 29.48

NS

5α-Androstanedione

36.43 ± 15.15 (11)

59.43 ± 12.34 (4)

NC

Estrogens

   

Estrone

71.16 ± 60.17

165.12 ± 138.61

< 0.008

17β-estradiol

20.78 ± 19.43

52.64 ± 42.82

< 0.008

Estriol

69.12 ± 55.60

197.03 ± 403.37

NS

2-hydroxyestrone

298.38 ± 272.41

126.11 ± 63.97

< 0.007

2-hydroxy-17β-estradiol

84.88 ± 60.34

283.06 ± 247.77

< 0.002

4-hydroxyestrone

72.78 ± 57.37

119.25 ± 54.27

< 0.02

4-hydroxy-17β-estradiol

37.69 ± 30.34

91.53 ± 49.54

< 0.0003

2-methoxyestrone

53.79 ± 96.35

94.21 ± 48.47

NS

2-methoxy-17β-estradiol

28.85 ± 23.85

43.09 ± 18.79

NS

4-methoxyestrone

36.30 ± 32.13

61.86 ± 29.64

< 0.04

4-methoxy-17β-estradiol

29.38 ± 19.95

61.79 ± 37.91

< 0.02

17-epiestriol

18.07 ± 8.07

97.53 ± 56.54

< 0.003

16-epiestriol

37.43 ± 16.97

83.48 ± 68.51

< 0.02

17α-estradiol

2.18 ± 1.98 (2)

ND

NC

2-hydroxyestriol

2.37 ± 2.74

85.99 ± 63.04

< 0.002

16-keto-17β-estradiol +

16α-hydroxyestrone

20.79 ± 11.75

70.92 ± 81.33

< 0.01

Corticoids

   

Cortisol

276.27 ± 348.99

194.98 ± 121.70

NS

Allodihydrocortisol

38.87 ± 26.40

24.27 ± 18.96

NS

Corticosterone

37.33 ± 28.36

54.26 ± 24.03

NS

Allodihydrocorticosterone

33.18 ± 26.19

42.48 ± 18.15

NS

Dihydrodeoxycorticosterone

97.57 ± 145.03

90.54 ± 53.46

NS

11-deoxycorticosterone

43.68 ± 27.30

48.25 ± 19.29

NS

11-deoxycortisol

59.55 ± 42.52

53.88 ± 37.00

NS

Cortisone

700.66 ± 691.13

828.94 ± 783.61

NS

Allotetrahydrocortisol

6987.19 ± 6000.57

14415.42 ± 17559.79

NS

21-deoxycortisol

69.17 ± 45.07

89.61 ± 80.03

NS

11-dehydrocorticosterone

131.08 ± 121.05

92.97 ± 93.87

NS

Tetrahydrodeoxycortisol

502.93 ± 336.31

547.57 ± 293.54

NS

Tetrahydrocortisone

12623.53 ± 9093.38

14081.85 ± 11546.70

NS

Tetrahydrocortisol

6038.33 ± 4364.60

10488.74 ± 9218.05

NS

Tetrahydrodeoxycorticosterone

72.07 ± 90.74

76.89 ± 88.78

NS

Tetrahydrocorticosterone

353.41 ± 307.84

589.34 ± 321.77

< 0.02

11-dehydrotetrahydrocorticosterone

1403.89 ± 610.28

992.50 ± 677.32

NS

α-cortolone

4989.28 ± 3076.48

5749.11 ± 3617.93

NS

β-cortolone

2030.16 ± 1204.44

2745.91 ± 1714.17

NS

20α-dihydrocortisone

340.09 ± 272.98

423.71 ± 252.98

NS

α-cortol

921.30 ± 645.85

884.54 ± 634.69

NS

β-cortol

2296.04 ± 1382.42

2602.54 ± 1638.69

NS

20α-dihydrocortisol

209.95 ± 260.36

130.72 ± 105.39

NS

Progestins

   

Pregnenolone

44.36 ± 33.00

73.78 ± 32.67

< 0.008

Progesterone

45.35 (1)

194.29 (1)

NC

5β-dihydroprogesterone

7.23 ± 5.09

7.88 (1)

NC

5α-dihydroprogesterone

53.83 ± 26.13

20.36 ± 25.60

< 0.04

20α-hydroprogesterone

125.50 ± 189.43

153.23 ± 126.74

NS

Epipregnanolone

19.10 ± 17.42

29.50 ± 12.29

NS

Pregnanolone

717.51 ± 900.30

1305.74 ± 2701.21

NS

Allopregnanolone

198.24 ± 255.64

188.66 ± 240.25

NS

Isopregnanolone

33.41 ± 13.44

73.87 ± 50.59

< 0.02

Pregnanediol

7025.27 ± 8837.04

14031.18 ± 31235.57

NS

Pregnanetriol

2874.08 ± 1477.34

5021.37 ± 4085.30

< 0.04

17α-hydroxypregnenolone

57.89 ± 42.96

87.99 ± 40.07

< 0.03

17α-hydroxyprogesterone

53.61 ± 43.13 (6)

97.95 ± 63.76 (2)

NC

11β-hydroxyprogesterone

938.19 ± 726.72

1557.51 ± 1150.75

< 0.05

Sterols

   

Cholesterol

4601.20 ± 9878.96

7633.19 ± 8383.76

NS

Desmosterol

167.78 ± 64.99

327.76 ± 127.00

NS

Lanosterol

76.86 ± 82.14

78.06 (1)

NC

20α-hydroxycholesterol

59.65 ± 52.14

93.08 ± 24.37

NS

24S-hydroxycholesterol

53.36 ± 35.45

66.87 ± 30.67

NS

  1. The number in the parentheses is the number of subject detected corresponding steroid.
  2. aConcentrations are expressed as ng/g of creatinine (mean ± SD).
  3. bNS, not significant.
  4. cNC, not comparable.