Steroids | Concentrationa (mean ± SD) | P-value | |
---|---|---|---|
Controls (n = 24) | PTC (n = 21) | Controls : PTC | |
Androgens | |||
Dihydrotestosterone | 65.79 ± 47.43 | 118.67 ± 61.89 | < 0.005 |
Epidihydrotestosterone | 20.21 ± 16.70 | 44.85 ± 18.85 | < 0.0007 |
Dehydroepiandrosterone | 151.34 ± 84.40 | 216.29 ± 93.00 | < 0.02 |
Testosterone | 64.73 ± 45.54 | 116.60 ± 24.77 | < 0.03 |
Epitestosterone | 82.61 ± 49.75 | 109.66 ± 42.13 | NSb |
5α-androstan-3α,17β-diol | 137.28 ± 90.96 | 202.60 ± 259.73 | NS |
5α-androstan-3β,17β-diol | 20.00 ± 11.75 (3) | 42.54 (1) | NCc |
5β-androstan-3α,17β-diol | 204.52 ± 149.53 | 248.07 ± 336.60 | NS |
5β-androstan-3α,17α-diol | 70.50 ± 49.49 | 107.26 ± 105.68 | NS |
5β-androstan-3β,17α-diol | 5.42 ± 1.69 (4) | 6.30 ± 1.45 (3) | NC |
5α-androstan-3β,17α-diol | 21.17 ± 14.55 | 41.20 ± 28.43 | NS |
5α-androstan-3α,17α-diol | 33.64 ± 26.33 | 53.18 ± 41.56 | NS |
5β-androstan-3β,17β-diol | 8.75 (1) | 36.84 ± 53.75 (4) | NC |
Androstenedione | 59.17 ± 50.56 | 96.93 ± 39.56 | < 0.01 |
Androstenediol | 51.71 ± 31.61 | 96.27 ± 33.98 | < 0.0002 |
Androsterone | 7826.70 ± 5459.40 | 24675.61 ± 23074.97 | < 0.004 |
Etiocholanolone | 7074.80 ± 4371.84 | 21993.33 ± 14558.44 | < 0.0002 |
11-keto-androsterone + 11-keto-etiocholanolone | 439.95 ± 320.79 | 2048.15 ± 1749.63 | < 0.0005 |
11β-hydroxyandrosterone | 2413.61 ± 1411.53 | 5197.95 ± 4501.89 | < 0.01 |
11β-hydroxyetiocholanolone | 1185.01 ± 873.09 | 2598.36 ± 1740.91 | < 0.003 |
5β-dihydrotestosterone | 3.97 ± 2.92 | 21.71 ± 9.26 | < 0.00008 |
16α-hydroxy-DHEA | 127.76 ± 67.50 | 285.48 ± 147.21 | < 0.0002 |
Epiandrosterone | 33.26 ± 26.59 | 49.45 ± 29.48 | NS |
5α-Androstanedione | 36.43 ± 15.15 (11) | 59.43 ± 12.34 (4) | NC |
Estrogens | |||
Estrone | 71.16 ± 60.17 | 165.12 ± 138.61 | < 0.008 |
17β-estradiol | 20.78 ± 19.43 | 52.64 ± 42.82 | < 0.008 |
Estriol | 69.12 ± 55.60 | 197.03 ± 403.37 | NS |
2-hydroxyestrone | 298.38 ± 272.41 | 126.11 ± 63.97 | < 0.007 |
2-hydroxy-17β-estradiol | 84.88 ± 60.34 | 283.06 ± 247.77 | < 0.002 |
4-hydroxyestrone | 72.78 ± 57.37 | 119.25 ± 54.27 | < 0.02 |
4-hydroxy-17β-estradiol | 37.69 ± 30.34 | 91.53 ± 49.54 | < 0.0003 |
2-methoxyestrone | 53.79 ± 96.35 | 94.21 ± 48.47 | NS |
2-methoxy-17β-estradiol | 28.85 ± 23.85 | 43.09 ± 18.79 | NS |
4-methoxyestrone | 36.30 ± 32.13 | 61.86 ± 29.64 | < 0.04 |
4-methoxy-17β-estradiol | 29.38 ± 19.95 | 61.79 ± 37.91 | < 0.02 |
17-epiestriol | 18.07 ± 8.07 | 97.53 ± 56.54 | < 0.003 |
16-epiestriol | 37.43 ± 16.97 | 83.48 ± 68.51 | < 0.02 |
17α-estradiol | 2.18 ± 1.98 (2) | ND | NC |
2-hydroxyestriol | 2.37 ± 2.74 | 85.99 ± 63.04 | < 0.002 |
16-keto-17β-estradiol + 16α-hydroxyestrone | 20.79 ± 11.75 | 70.92 ± 81.33 | < 0.01 |
Corticoids | |||
Cortisol | 276.27 ± 348.99 | 194.98 ± 121.70 | NS |
Allodihydrocortisol | 38.87 ± 26.40 | 24.27 ± 18.96 | NS |
Corticosterone | 37.33 ± 28.36 | 54.26 ± 24.03 | NS |
Allodihydrocorticosterone | 33.18 ± 26.19 | 42.48 ± 18.15 | NS |
Dihydrodeoxycorticosterone | 97.57 ± 145.03 | 90.54 ± 53.46 | NS |
11-deoxycorticosterone | 43.68 ± 27.30 | 48.25 ± 19.29 | NS |
11-deoxycortisol | 59.55 ± 42.52 | 53.88 ± 37.00 | NS |
Cortisone | 700.66 ± 691.13 | 828.94 ± 783.61 | NS |
Allotetrahydrocortisol | 6987.19 ± 6000.57 | 14415.42 ± 17559.79 | NS |
21-deoxycortisol | 69.17 ± 45.07 | 89.61 ± 80.03 | NS |
11-dehydrocorticosterone | 131.08 ± 121.05 | 92.97 ± 93.87 | NS |
Tetrahydrodeoxycortisol | 502.93 ± 336.31 | 547.57 ± 293.54 | NS |
Tetrahydrocortisone | 12623.53 ± 9093.38 | 14081.85 ± 11546.70 | NS |
Tetrahydrocortisol | 6038.33 ± 4364.60 | 10488.74 ± 9218.05 | NS |
Tetrahydrodeoxycorticosterone | 72.07 ± 90.74 | 76.89 ± 88.78 | NS |
Tetrahydrocorticosterone | 353.41 ± 307.84 | 589.34 ± 321.77 | < 0.02 |
11-dehydrotetrahydrocorticosterone | 1403.89 ± 610.28 | 992.50 ± 677.32 | NS |
α-cortolone | 4989.28 ± 3076.48 | 5749.11 ± 3617.93 | NS |
β-cortolone | 2030.16 ± 1204.44 | 2745.91 ± 1714.17 | NS |
20α-dihydrocortisone | 340.09 ± 272.98 | 423.71 ± 252.98 | NS |
α-cortol | 921.30 ± 645.85 | 884.54 ± 634.69 | NS |
β-cortol | 2296.04 ± 1382.42 | 2602.54 ± 1638.69 | NS |
20α-dihydrocortisol | 209.95 ± 260.36 | 130.72 ± 105.39 | NS |
Progestins | |||
Pregnenolone | 44.36 ± 33.00 | 73.78 ± 32.67 | < 0.008 |
Progesterone | 45.35 (1) | 194.29 (1) | NC |
5β-dihydroprogesterone | 7.23 ± 5.09 | 7.88 (1) | NC |
5α-dihydroprogesterone | 53.83 ± 26.13 | 20.36 ± 25.60 | < 0.04 |
20α-hydroprogesterone | 125.50 ± 189.43 | 153.23 ± 126.74 | NS |
Epipregnanolone | 19.10 ± 17.42 | 29.50 ± 12.29 | NS |
Pregnanolone | 717.51 ± 900.30 | 1305.74 ± 2701.21 | NS |
Allopregnanolone | 198.24 ± 255.64 | 188.66 ± 240.25 | NS |
Isopregnanolone | 33.41 ± 13.44 | 73.87 ± 50.59 | < 0.02 |
Pregnanediol | 7025.27 ± 8837.04 | 14031.18 ± 31235.57 | NS |
Pregnanetriol | 2874.08 ± 1477.34 | 5021.37 ± 4085.30 | < 0.04 |
17α-hydroxypregnenolone | 57.89 ± 42.96 | 87.99 ± 40.07 | < 0.03 |
17α-hydroxyprogesterone | 53.61 ± 43.13 (6) | 97.95 ± 63.76 (2) | NC |
11β-hydroxyprogesterone | 938.19 ± 726.72 | 1557.51 ± 1150.75 | < 0.05 |
Sterols | |||
Cholesterol | 4601.20 ± 9878.96 | 7633.19 ± 8383.76 | NS |
Desmosterol | 167.78 ± 64.99 | 327.76 ± 127.00 | NS |
Lanosterol | 76.86 ± 82.14 | 78.06 (1) | NC |
20α-hydroxycholesterol | 59.65 ± 52.14 | 93.08 ± 24.37 | NS |
24S-hydroxycholesterol | 53.36 ± 35.45 | 66.87 ± 30.67 | NS |