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Table 1 EC50 (μmol/L) for P3155 and topotecan (standard) in the HIF-1α reporter gene based assay

From: A novel inhibitor of hypoxia-inducible factor-1α P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells

Sr. No.

Compound No

EC50 (μmol/L)

EC50 (μmol/L)

  

U251-HRE (Hypoxia/DFX)

U251-pGL3 (normoxia)

01

P3155

1.4

> 10

02

Topotecan

0.06

> 3.0

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BMC Cancer

ISSN: 1471-2407

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