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Table 1 EC50 (μmol/L) for P3155 and topotecan (standard) in the HIF-1α reporter gene based assay

From: A novel inhibitor of hypoxia-inducible factor-1α P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells

Sr. No. Compound No EC50 (μmol/L) EC50 (μmol/L)
   U251-HRE (Hypoxia/DFX) U251-pGL3 (normoxia)
01 P3155 1.4 > 10
02 Topotecan 0.06 > 3.0
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BMC Cancer

ISSN: 1471-2407

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