Diagnostic accuracy forest plots. Forest plots of the overall sensitivity (A), specificity (B), positive likelihood ratio (LR+) (C), and negative likelihood ratio (LR-) (D) of circulating tumor cell detection are presented. The size of each square is proportional to sample size. Horizontal lines in each square show the corresponding 95% confidence intervals (CI). The center of the diamond indicates the overall sensitivity, specificity, LR+, and LR- and the ends correspond to 95%CI.