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Table 6 Nucant pseudopeptides inhibit proliferation of human colon carcinoma cells.

From: Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type

Cells

Nucant

Number of cells

% inhibition

SW480

None: Control

1,500,000

-

 

N7: 10 μM

1,200,000

20%

 

N7: 20 μM

900,000

40%

 

N6L: 10 μM

800,000

47%

SW620

None: Control

1,800,000

-

 

N7: 10 μM

1,000,000

44%

 

N7: 20 μM

700,000

61%

 

N6L: 10 μM

450,000

75%

  1. Cells seeded in 6-well plates at 20,000 cells/ml in 2 ml culture medium were cultured in the absence (Control) or presence of N7 and N6L. Seven days after seeding, cells were trypsinized and counted. Nucant pseudopeptides were added only once 5 hours after seeding of cells. Consistently, N6L manifests at least 2-fold higher inhibitory activity compared to N7.
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BMC Cancer

ISSN: 1471-2407

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