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Table 5 Inhibitory activity of N3, N6, and N6L on melanoma TIII cell adhesion and proliferation.

From: Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type

Nucant

% Inhibition of cell

 

Adhesion

Proliferation

N3: 5 μM

No effect

No effect

N3: 10 μM

15%

10%

N3: 20 μM

24%

36%

N6: 2.5 μM

15%

12%

N6: 5 μM

26%

20%

N6: 10 μM

38%

32%

N6: 20 μM

55%

45%

N6L: 2.5 μM

39%

45%

N6L: 5 μM

49%

56%

N6L: 10 μM

65%

80%

N6L: 20 μM

72%

85%

  1. Epithelial melanoma TIII cells were cultured in the absence or presence of different concentrations of N3, N6, and N6L to monitor inhibition of cell adhesion (after 5 hours of cell seeding) and cell proliferation (after 3 days of culture). The number of viable cells in untreated control samples was used to calculate % inhibition of cell adhesion and proliferation. The mean percentage values of at least 2 independent experiments are presented.