Skip to main content
Figure 3 | BMC Cancer

Figure 3

From: Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type

Figure 3

HB-19 and related Nucant pseudopeptides inhibit the production of TNF-α and IL-6 by peripheral blood lymphocytes. The production of pro-inflammatory cytokines in PBMC cultures stimulated with HKSA was carried out in triplicate in the absence (Control) or presence of 10 μM of each of HB-19, N3, N6, N7, N6L, or 1 μg/ml of dexamethasone (Dex.)(Methods). The level of TNF-α (section A) and IL-6 (section B) was monitored in culture supernatants by ELISA. The data presents the mean ± SD of triplicate samples. The degree of inhibition is indicated at the top of each histogram. Statistical significance: **p < 0.01, ***p < 0.001.

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us