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Table 4 Genes significantly differentially expressed according to serum estradiol levels in breast carcinomas.

From: Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas

 

Gene Name

AREG

GREB1

TFF3 7)

TFF3 7)

TFF1

A

Chromosomal location

4q13-21

2p25.1

21q22.3

21q22.3

21q22.3

 

q-value (%) SAM all tumors1)

0

0

20.5

20.5

20.5

 

Gene expression in high s-est

     
 

(compared with low s-est)2)

up

up

up

up

up

 

q-value (%) SAM ER+ BC1)3)

0

0

-

-

-

 

Gene expression in high s-est

     
 

(compared with low s-est)2)

up

up

-

-

-

B

BC4) vs normal breast tissue5

0.38

0.18

4.80E-05

2.60E-04

1.20E-07

 

Gene expression in BC4)

     
 

(compared with normal)

-

-

up

up

up

 

ER+ vs ER- BC4) 5

0.08

4.80E-08

2.00E-06

2.40E-07

0.002

 

Gene expression in ER+ BC

     
 

(compared with ER- BC6))

up

up

up

up

up

  1. A) Quantitativ SAM analysis for differential expression according to serum estradiol with q-values and direction of regulation indicated. B) Significance testing of difference in gene expression of the genes identified in A) in different sample cohorts.
  2. 1) Q-value from SAM of gene expression according to serum estradiol
  3. 2) Gene expression in samples from patients with high compared with low serum estradiol
  4. 3) ER+ BC = Estrogen receptor positive breast cancer (n = 53)
  5. 4) BC = breast cancer
  6. 5) P-value from two-sided t-test
  7. 6) ER- BC = Estrogen receptor negative breast cancer (n = 8)
  8. 7) Two different probes for TFF3 are used