Figure 3
From: Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice
Effect of hypoxia to hypoxia for 10 days or 7 days on tumor growth of lung cancer in rats. (A to E) Exposure to hypoxia for 10 days in xenograft model (Figure 1C) : (A) Tumor growth curve, (B) Tumor weight, (C) ratio of tumor weight to body weight, (D) Distribution of tumor size (upper panel) and representative tumor samples (lower panel), (E) Hematocrit. *p < 0.05 as compared with normoxia. n = 21 for normoxia group and 22 for hypoxia group. (F & G) Exposure to hypoxia for 7 days in xenograft model (Figure 1D): (F) Tumor growth curve and (G) tumor weight. n = 5 for each group. *p < 0.05 as compared with normoxia. (H & I) Exposure to hypoxia for 10 days in orthotopic model (Figure 1C): (H) Tumor weight and (I) lymph node number from orthotopic rats exposed to hypoxia for 10 days. *p < 0.05 as compared with normoxia. n = 5 for each group.