From: Rationale and design of the Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research Trial (MANTICORE 101 - Breast): a randomized, placebo-controlled trial to determine if conventional heart failure pharmacotherapy can prevent trastuzumab-mediated left ventricular remodeling among patients with HER2+ early breast cancer using cardiac MRI
Placebo
Δ LVEDV
at 1 year
Perindopril
% Remodeling prevented
+11%
+1%
90%
+11.7%
+1.9%
84%
+12.5%
+2.75%
78%
+14.2%
+4.4%
69%
+15.8%
+6.1%
62%