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Table 4 Murine serum IGF-1 concentrations during the ketogenic diet

From: Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

  days post tumor cell implantation
  14 24 38 65-115
  control KD control KD control KD control KD
animals 4 4 3 3 3 3 10 9
IGF-1 [ng/mL] 245.0
± 50.3
310.3
± 36.8
310.0
± 28.9
417.5
± 106.1
312.7
± 84.9
301.9
± 36.5
242.8
± 53.2
292.2
± 58.1
  1. After LNT-229 tumor cell implantation at day 0, animals were randomized into two diet groups, a standard diet versus a ketogenic diet (day 1). On days 14, 24 and 38 as well as at the end of the experiment (days 65-115), serum was obtained by centrifugation of whole blood at 2000 g for 10 min and subsequently stored at -80°C. Murine IGF-1 serum levels determined by immunoassay were not significantly different between diet groups (KD, ketogenic diet; mean and standard deviation).