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Figure 3 | BMC Cancer

Figure 3

From: Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer

Figure 3

Immunohistochemical expression of MCTs and CD147 in normal, PIN lesions and neoplastic prostate tissue. MCT1 immunoreactivity in normal glands (A), PIN lesions (B) and malignant glands (C) was observed in the basal and lateral epithelial cell membranes (solid arrow head) with no immunoreaction in the apical zone (open arrow head). MCT2 immunoreactivity in normal (D), PIN lesions (E), malignant glands (F) was mainly observed in the cytoplasm of epithelial cells, being absent in the normal glands (solid arrow head) but with strong granular pattern in malignant glands and PIN lesion (open arrow head). MCT4 immunoreactivity in normal glands (G), PIN lesions (H) malignant glands (I) was observed in the cytoplasm, with granular appearance (open arrow head), being absent in normal glands (solid arrow head). CD147 immunoreactivity in normal glands (J), PIN lesions (K) and malignant glands (L) was observed in the basal and lateral epithelial cell membranes (solid arrow head), with no immunoreaction in the apical zone (open arrow head). Main pictures are at 200× magnification and insets are at 400×.

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