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Table 4 Differentially expressed genes selected in samples mutated for EGFR TK domain.

From: Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer

EntrezGene

Gene Name

Description

Log10Ratio *

2952

GSTT1

Glutathione S-transferase theta-1

↓

10257

ABCC4

Multidrug resistance-associated protein 4

↓

1657

DMXL1

DmX-like protein 1

↓

25800

SLC39A6

Zinc transporter ZIP6 Precursor

↓

55840

EAF2

ELL-associated factor 2

↓

354

KLK3

Prostate-specific antigen Precursor (PSA)

↓

81035

COLEC12

Collectin-12 (Collectin placenta protein 1)

↓

10788

IQGAP2

Ras GTPase-activating-like protein

↓

123036

MTAC2D1

Tandem C2 domains nuclear protein

↓

3150

HMGN1

Non-histone chromosomal protein HMG-14

↓

55359

STYK1

Tyrosine protein-kinase

↓

64757

MOSC1

MOSC domain-containing protein 1, mitochondrial Precursor

↓

5269

SERPINB6

Serpin B6 (Placental thrombin inhibitor)

↓

1066

ANXA3

Annexin A3

↓

652708

CES1

Liver carboxylesterase 1 Precursor

↑

220164

DOK6

Docking protein 6 (Downstream of tyrosine kinase 6)

↑

2296

FOXC1

Forkhead box protein C1

↑

219699

UNC5B

etrin receptor UNC5B Precursor

↑

2070

EYA4

Eyes absent homolog 4

↑

10964

IFI44L

Interferon-induced protein 44-like

↑

678

ZFP36L2

Butyrate response factor 2

↑

64710

NUCKS1

Nuclear ubiquitous casein and cyclin-dependent kinases substrate (P1)

↑

10365

KLF2

Krueppel-like factor 2

↑

1783

DYNC1LI2

Cytoplasmic dynein 1 light intermediate chain 2

↑

79884

MAP9

Microtubule-associated protein 9

↑

2813

GP2

Pancreatic secretory granule membrane major glycoprotein GP2 Precursor

↑

22888

UBOX5

RING finger protein 37

↑

  1. * Log10Ratio: logarithm (base 10) of the ratio between PC sample and prostate reference expression values. ↑: up regulated gene. ↓: down-regulated gene