Table 2 Increased expression of cell cycle regulators as during naïve tumor growth by GSEA.
From: Integrated genomics of ovarian xenograft tumor progression and chemotherapy response
Geneset | NES | P-value | FDR GSEA |
|---|---|---|---|
Naïve Tumor 8 day vs. 16 day |  |  |  |
BioCarta (n = 184) | Â | Â | Â |
Cell cycle pathway | -2.06 | 0.000 | 0.065 |
Kegg (n = 165) | Â | Â | Â |
Ribosome | 2.25 | 0.000 | 0.000 |
Cell Cycle | -2.34 | 0.000 | 0.000 |
Proteasome | -1.72 | 0.000 | 0.088 |
GenMapp (n = 107) | Â | Â | Â |
DNA replication reactome | -2.13 | 0.000 | 0.003 |
Cholesterol Biosynthesis | -1.89 | 0.012 | 0.024 |
TFT (n = 614) | Â | Â | Â |
E2F_Q3 | -1.84 | 0.000 | 0.039 |
E2F1_Q6 | -1.76 | 0.000 | 0.027 |
Gene Ontology (n = 1307) | Â | Â | Â |
M phase of mitotic cell cycle | -2.15 | 0.000 | 0.008 |
M phase | -2.17 | 0.000 | 0.007 |
Mitosis | -2.18 | 0.000 | 0.008 |
MT19C 8 day vs. 16 day | Â | Â | Â |
GenMapp (n = 107) | Â | Â | Â |
DNA Replication Reactome | 1.74 | 0.000 | 0.056 |
Ribosomal Proteins | -2.44 | 0.000 | 0.000 |
Proteasome | -1.76 | 0.016 | 0.091 |
Kegg (n = 165) | Â | Â | Â |
Cell Cycle | 1.68 | 0.004 | Â |
Apoptosis | -1.54 | 0.016 | 0.164 |
Transcription Factor Targets (n = 614) | Â | Â | Â |
E2F_Q4 | 1.83 | 0.000 | 0.025 |
E2F1_Q6 | 1.77 | 0.000 | 0.018 |
NFKB | -1.79 | 0.000 | 0.021 |
AP1 | -1.78 | 0.000 | 0.024 |
NFKAPPAB | -1.52 | 0.000 | 0.063 |