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Table 2 Increased expression of cell cycle regulators as during naïve tumor growth by GSEA.

From: Integrated genomics of ovarian xenograft tumor progression and chemotherapy response

Geneset NES P-value FDR GSEA
Naïve Tumor 8 day vs. 16 day    
BioCarta (n = 184)    
Cell cycle pathway -2.06 0.000 0.065
Kegg (n = 165)    
Ribosome 2.25 0.000 0.000
Cell Cycle -2.34 0.000 0.000
Proteasome -1.72 0.000 0.088
GenMapp (n = 107)    
DNA replication reactome -2.13 0.000 0.003
Cholesterol Biosynthesis -1.89 0.012 0.024
TFT (n = 614)    
E2F_Q3 -1.84 0.000 0.039
E2F1_Q6 -1.76 0.000 0.027
Gene Ontology (n = 1307)    
M phase of mitotic cell cycle -2.15 0.000 0.008
M phase -2.17 0.000 0.007
Mitosis -2.18 0.000 0.008
MT19C 8 day vs. 16 day    
GenMapp (n = 107)    
DNA Replication Reactome 1.74 0.000 0.056
Ribosomal Proteins -2.44 0.000 0.000
Proteasome -1.76 0.016 0.091
Kegg (n = 165)    
Cell Cycle 1.68 0.004  
Apoptosis -1.54 0.016 0.164
Transcription Factor Targets (n = 614)    
E2F_Q4 1.83 0.000 0.025
E2F1_Q6 1.77 0.000 0.018
NFKB -1.79 0.000 0.021
AP1 -1.78 0.000 0.024
NFKAPPAB -1.52 0.000 0.063
  1. NES > 1.4 indicates higher expression in 8 day naïve tumors compared to 16 day. NES < -1.4 indicates higher expression in 16 day naïve tumors compared to 8 day.