Skip to main content

Table 1 Gene Set Enrichment Analysis reveals MT19C down-regulation of energy metabolism and stimulation of DNA repair and apoptosis pathways.

From: Integrated genomics of ovarian xenograft tumor progression and chemotherapy response

Geneset

NES

P-value

FDR GSEA

Kegg (n = 165)

   

Cell Communication

-1.97

0.000

0.029

Biosynthesis of Steroids

-1.95

0.002

0.046

Galactose metabolism

-1.84

0.005

0.082

Oxidative Phosphorylation

-1.69

0.000

0.102

Notch signaling pathway

-1.49

0.032

0.232

Ubiquitin mediated Proteolysis

1.98

0.000

0.021

Gene Ontology (n = 1307)

   

Double Strand Break Repair

1.86 (1.85)

0.000 (0.006)

0.006

Ubiquitin Cycle

2.01 (1.96)

0.000 (0.000)

0.111

  1. NES > 1.4 indicates enriched in MT19C treated tumors compared to naïve tumors for all 8 and 16 day tumors, including T16C.