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Table 2 Effects of Aca1 and SU1498 on LN18 CM-induced ES formation by HUVEC.

From: Glioblastoma-derived Leptin Induces Tube Formation and Growth of Endothelial Cells: Comparison with VEGF Effects

Conditions

ES (%)

LN18 CM

100.0

LN18 CM + Aca1 10 nM

62.0 ± 11.5

LN18 CM + Aca1 25 nM

55.0 ± 1.4

LN18 CM + Aca1 50 nM

52.0 ± 8.5

LN18 CM + SU1498 1 μM

55.0 ± 5.5

LN18 CM + Aca1 10 nM + SU1498 1 μM

35.0 ± 7.5

LN18 CM + SU1498 5 μM

25.0 ± 3.5

LN18 CM + Aca1 10 nM + SU1498 5 μM

10.2 ± 3.2

  1. Tube-like formation assay was performed in LN18-derived CM mixed (1:1) with VCBM, containing or not Aca1 and/or SU1498 for 24 h, as described in Materials and Methods. The table shows the relative increase of ES formation (%), with LN18 CM taken as reference (100%). Means ± SD are shown.