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Figure 4 | BMC Cancer

Figure 4

From: Glioblastoma-derived Leptin Induces Tube Formation and Growth of Endothelial Cells: Comparison with VEGF Effects

Figure 4

Aca1 and SU1498 inhibit angiogenic and mitogenic effects of LN18 CM. A) Representative phase contrast images (magnification 10×) of ES formed by HUVEC grown for 24 h in SFM or LN18-derived CM containing or not 50 nM Aca1 and/or 5 μM SU1498. B) HUVEC were grown for 48 h in CM mixed (1:1) with VCBM, containing 10, 25 or 50 nM Aca1 and/or 5 μM SU1498 as described in Materials and Methods. The graph represents relative growth increase, with CM taken as reference (100%). Columns, mean of at least three independent experiments done in triplicates; bars, SE. * P < 0,05 and ** P < 0,01 (CM + Aca1 or CM + SU1498 5 μM vs. CM alone, CM + Aca1/SU1498 5 μM vs. CM + Aca1 and CM + SU1498 5 μM).

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