Radiotherapy may improve overall survival of patients with T3/T4 transitional cell carcinoma of the renal pelvis or ureter and delay bladder tumour relapse

Table 3 Univariate and multivariate analysis of predictors of bladder tumor relapse in 133 patients with TCC of the renal pelvis or ureter

Variables	n	Bladder tumor relapse		X²	p values
		Absent (n = 95)	Present (n = 38)		univariate	multivariate
Age
< 60 years	31	23(74.2%)	8(25.8%)	0.697	0.573	0.562
≥ 60 years	102	72(70.6%)	30(29.4%)
Sex
Female	50	33(66.0%)	17(34.0%)	0.282	0.277	0.588
Male	83	62(74.7%)	21(25.3%)
Tumor location
Renal pelvis	42	36(85.7%)	6(14.3%)	0.013	0.048	0.015
Ureter	91	59(64.8%)	32(35.2%)
Tumor lesions
Solitary	117	83(70.9%)	34(29.1%)	0.736	0.628	0.352
Multiple nodules	16	12(75.0%)	4(25.0%)
pT classification
T1 or T2	81	59(72.8%)	22(27.2%)	0.653	0.255	0.256
T3 or T4	52	36(69.2%)	16(30.8%)
Synchronous LN
-	124	88(71.0%)	36(29.0%)	0.662	0.687	0.759
+	9	7(77.8%)	2(22.2%)
Resection models
Local resection	22	17(77.3%)	5(22.7%)	0.507	0.853	0.543
Radical resection	111	78(70.3%)	33(29.7%)
Residual Disease
R0	108	78(72.2%)	30(27.8%)	0.674	0.148	0.167
R1 or R2	25	17(68.0%)	8(32.0%)
Histological grade
Grade I or II	79	55(69.6%)	24(30.4%)	0.577	0.926	0.816
Grade III or IV	54	40(74.1%)	14(25.9%)
EBRT
Non-EBRT	66	43(65.2%)	23(34.8%)	0.112	0.060	0.514
EBRT w/o bladder	67	52(77.6%)	15(22.4%)
RT including bladder
No	80	49(61.3%)	31(38.7%)	0.001	0.002	< 0.001
Yes	53	46(86.8%)	7(13.2%)

No lymph node metastasis was found in pT1 or T2 patients, so patients with T3 or T4 are equal to those with AJCC stage III or IV in this study. We did not use AJCC Stage III or IV in this table, because we excluded patients with distant metastases from our study, who are also regarded as stage IV.
TCC: Transitional Cell arcinoma; LN: Lymph Node; EBRT: External Beam Radiation Therapy

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