Figure 9From: A cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells Acidification response of human cancer cells to C7a. Cells were placed on the Cytosensor System and allowed to equilibrate in low buffered RPMI containing 1% BSA to normalize the acidification rate in 100% (Buffer). C7a and Cisplatin were diluted in the same medium, added at zero time and maintained during the whole assay. Cells were monitored every 2 min. (A) HCT-8 cells; (B) SiHa cells; (C) SKmel25 cells. Results are representative of 2 independent experiments.Back to article page