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Figure 7 | BMC Cancer

Figure 7

From: A cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells

Figure 7

Caspase activation and nuclear alterations after treatment with C7a. (A) Activation of caspases after C7a treatment measured by a colorimetric assay. Ctrl, untreated tumor cells; UV, positive control, cells submitted to UV irradiation. (B) Percentage of activated caspase-3-positive cells in flow citometry after Actinomycin D or C7a treatment. Control, untreated tumor cells incubated with anti-active caspase 3 antibody. (C) Representative images of C7a-treated B16F10-Nex2 cells after nuclear staining with Hoescht 33342. Arrows represent nuclear alterations. Magnification, 400 ×, and scale bars, 20 μm. Results are representative of at least 2 independent experiments.

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BMC Cancer

ISSN: 1471-2407

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