Skip to main content
Figure 4 | BMC Cancer

Figure 4

From: A cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells

Figure 4

Bax translocation to mitochondria in GFP-Bax-transfected B16F10-Nex2 cells after treatment with C7a is dependent on Ca 2+. (A) Representative images of untreated cells and after 3 h treatment; (B) Representative images after selected time points of an individual tumor cell; (C) The same assay performed in (B) with transfected cells preincubated with 20 μM of BAPTA before C7a addition; (D) Representative images show Bax-transfected C7a-treated cells after 2 h (1), co-stained with TMRE (2) and overlayed image (3). Scale bars, 20 μm in (A), 40 μm in (B) an (C) and 30 μm in (D). Images are representative of at least three individual experiments.

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us