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Table 4 ORs of erythema for different polymorphisms and their combination

From: Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of developing erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery

Polymorphisms

Genotype

Percentage

of ≥G1

OR

(95% CI)

Chi-squared p-value

Fisher's exact test p-value

XRCC1 Arg194Trp

(Aa/aa)

8%

1

  
 

(AA)

41%

8.07 (1.02-373.8)

0.026

0.042

XRCC3 Thr241Met

(Aa/aa)

41%

1

  
 

(AA)

17%

0.29 (0.05-1.29)

0.07

0.081

XRCC3 A4541G (5'UTR)

(aa)

50%

1

  
 

(AA/Aa)

33%

0.49 (0.01-40.29)

0.611

1

XRCC1 Arg194Trp/ GSTP1

Others

50%

1

  
 

XRCC1(Aa/aa)

or GSTP1 (Aa/aa)

23%

0.3 (0.08-1.08)

0.034

0.046

XRCC1 Arg194Trp/ XRCC3 Thr241Met §

Others

48%

1

  
 

XRCC1 (Aa/aa) or

XRCC3 (AA)

15%

0.2 (0.04-0.78)

0.008

0.011

XRCC1 Arg194Trp/ XRCC1 Arg399Gln

Others

46%

1

  
 

XRCC1 Arg194Trp

(Aa/aa) or XRCC1

Arg399Gln (AA)

24%

0.39 (0.1-1.35)

0.088

0.099

XRCC1 Arg194Trp/ GSTA1 #

Others

11%

1

  
 

XRCC1 (Aa/aa) or

GSTA1 (AA)

44%

6.01 (1.16-61.04)

0.016

0.018

  1. Abbreviations: OR = odds ratio; calculated to homozygous normal genotype; 95% CI = 95% confidence interval.
  2. § α = 0.05, 2-tailed power (1-β = 78%; α = 0.05, 1- tailed power > 80%
  3. # α = 0.05, 2-tailed power (1-β = 75%; α = 0.05, 1- tailed power > 80%
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BMC Cancer

ISSN: 1471-2407

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