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Table 4 ORs of erythema for different polymorphisms and their combination

From: Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of developing erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery

Polymorphisms Genotype Percentage
of ≥G1
OR
(95% CI)
Chi-squared p-value Fisher's exact test p-value
XRCC1 Arg194Trp (Aa/aa) 8% 1   
  (AA) 41% 8.07 (1.02-373.8) 0.026 0.042
XRCC3 Thr241Met (Aa/aa) 41% 1   
  (AA) 17% 0.29 (0.05-1.29) 0.07 0.081
XRCC3 A4541G (5'UTR) (aa) 50% 1   
  (AA/Aa) 33% 0.49 (0.01-40.29) 0.611 1
XRCC1 Arg194Trp/ GSTP1 Others 50% 1   
  XRCC1(Aa/aa)
or GSTP1 (Aa/aa)
23% 0.3 (0.08-1.08) 0.034 0.046
XRCC1 Arg194Trp/ XRCC3 Thr241Met § Others 48% 1   
  XRCC1 (Aa/aa) or
XRCC3 (AA)
15% 0.2 (0.04-0.78) 0.008 0.011
XRCC1 Arg194Trp/ XRCC1 Arg399Gln Others 46% 1   
  XRCC1 Arg194Trp
(Aa/aa) or XRCC1
Arg399Gln (AA)
24% 0.39 (0.1-1.35) 0.088 0.099
XRCC1 Arg194Trp/ GSTA1 # Others 11% 1   
  XRCC1 (Aa/aa) or
GSTA1 (AA)
44% 6.01 (1.16-61.04) 0.016 0.018
  1. Abbreviations: OR = odds ratio; calculated to homozygous normal genotype; 95% CI = 95% confidence interval.
  2. § α = 0.05, 2-tailed power (1-β = 78%; α = 0.05, 1- tailed power > 80%
  3. # α = 0.05, 2-tailed power (1-β = 75%; α = 0.05, 1- tailed power > 80%