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Table 3 Incidence rates of bone metastases among breast cancer patients, and incidence rates of skeletal-related events (SREs) among breast cancer patients with bone metastases, from the first year after primary diagnosis of breast cancer and bone metastases, respectively, up to five years after diagnosis, Denmark, 1999-2007.

From: Incidence of bone metastases and skeletal-related events in breast cancer patients: A population-based cohort study in Denmark

  Event n Year 1 Year 2 - Year 5 Year 1 - Year 5
    Per 1,000 person-years (95% CI)
All patients Bone metastasis 1,272 13.6
(12.4 - 14.9)
8.8
(8.2 - 9.5)
10.2
(9.6 - 10.8)
  First SRE 712 759.2
(662.0 - 870.5)
513.8
(465.4 - 567.3)
578.0
(533.4 - 626.2)
Localized Bone metastasis 237 3.3
(2.5 - 4.4)
3.9
(3.3 - 4.5)
3.7
(3.2 - 4.3)
  First SRE 117 503.1
(285.7 - 885.9)
574.7
(462.8 - 713.5)
564.4
(461.1 - 690.9)
Regional Bone metastasis 663 12.9
(11.1 - 15.1)
13.5
(12.3 - 14.8)
13.3
(12.3 - 14.5)
  First SRE 310 774.6
(596.1 - 1006.5)
560.7
(490.7 - 640.6)
594.5
(527.8 - 669.5)
Distant Bone metastasis 358 172.5
(147.9 - 201.4)
49.7
(38.8 - 63.6)
101.8
(89.3 - 116.0)
  First SRE 176 760.1
(620.9 - 930.4)
421.5
(329.9 - 538.5)
573.5
(490.7 - 670.2)