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Table 2 Pathways significantly enriched by differentially expressed genes regulated by LH (p-value < 0.5)

From: Regulation of gene expression in ovarian cancer cells by luteinizing hormone receptor expression and activation

21 pathways uniquely involved in the up-regulated genes

Pathway (up-regulated genes involved)

LHR+

LH1

LH4

LH8

LH20

Gap junction

3

   

5

Melanogenesis

 

3

5

4

5

Toll-like receptor signaling pathway

 

3

  

8

Epithelial cell signaling in Helicobacter pylori infection

 

3

4

 

3

VEGF signaling pathway

  

4

 

4

Adherens junction

  

5

3

3

B cell receptor signaling pathway

  

3

 

6

Adipocytokine signaling pathway

  

3

 

4

Hedgehog signaling pathway

  

3

  

Basal cell carcinoma

  

3

  

Cell adhesion molecules (CAMs)

    

3

Long-term potentiation

    

3

Glutathione metabolism

    

5

Long-term depression

    

4

Androgen and estrogen metabolism

    

4

Dorso-ventral axis formation

    

3

mTOR signaling pathway

    

3

Metabolism of xenobiotics by cytochrome P450

    

5

Arachidonic acid metabolism

    

3

Fc epsilon RI signaling pathway

    

6

GnRH signaling pathway

    

3

22 pathways uniquely involved in the down-regulated genes

Pathway (down-regulated genes involved)

LHR+

LH1

LH4

LH8

LH20

Cell cycle

3

 

11

3

14

p53 signaling pathway

3

   

10

Complement and coagulation cascades

7

   

4

Pyrimidine metabolism

    

8

Alanine and aspartate metabolism

    

5

Urea cycle and metabolism of amino groups

    

6

Valine, leucine and isoleucine degradation

    

4

Propanoate metabolism

    

3

Neurodegenerative Diseases

    

3

Pyruvate metabolism

    

3

Alkaloid biosynthesis II

    

3

Glycerolipid metabolism

    

3

Carbon fixation

    

3

SNARE interactions in vesicular transport

    

3

beta-Alanine metabolism

    

4

Arginine and proline metabolism

    

4

Methionine metabolism

    

3

Selenoamino acid metabolism

    

3

Aminoacyl-tRNA biosynthesis

    

4

Phenylalanine metabolism

    

5

Glutamate metabolism

    

3

Basal transcription factors

    

3

34 pathways involved in both up- and down-regulated genes

Pathway (both up-/down-regulated genes involved)

LHR+

LH1

LH4

LH8

LH20

MAPK signaling pathway

4

8

9

6

15

 

3

 

3

 

12

Apoptosis

    

7

 

4

   

6

Focal adhesion

 

3

6

4

21

 

12

   

9

Regulation of actin cytoskeleton

3

3

5

 

16

 

3

 

3

 

7

TGF-beta signaling pathway

 

4

7

4

7

 

3

   

4

Cell Communication

    

11

 

13

    

ECM-receptor interaction

    

15

 

10

    

Jak-STAT signaling pathway

 

4

6

 

8

    

3

4

Tight junction

  

3

 

4

     

4

ErbB signaling pathway

  

3

 

5

 

4

   

4

Wnt signaling pathway

  

4

  
     

7

PPAR signaling pathway

    

3

     

3

Purine metabolism

3

 

3

3

4

     

8

Cytokine-cytokine receptor interaction

 

9

13

5

12

 

8

 

3

 

8

Axon guidance

  

6

3

11

 

4

   

6

Prostate cancer

 

3

5

3

8

     

5

Hematopoietic cell lineage

  

5

6

7

 

3

    

Natural killer cell mediated cytotoxicity

  

4

 

6

 

4

    

Neuroactive ligand-receptor interaction

  

3

 

3

 

6

   

3

Calcium signaling pathway

3

  

3

6

 

4

   

7

Insulin signaling pathway

  

4

 

5

     

6

Glycerophospholipid metabolism

  

4

 

5

     

3

Complement and coagulation cascades

  

3

 

7

 

7

   

4

Tryptophan metabolism

  

3

 

5

     

4

T cell receptor signaling pathway

  

3

 

6

     

3

Starch and sucrose metabolism

    

3

 

4

   

3

Leukocyte transendothelial migration

    

11

 

5

   

4

Nitrogen metabolism

    

6

     

3

Phosphatidylinositol signaling system

    

3

     

3

Tyrosine metabolism

    

3

     

6

Histidine metabolism

    

3

     

4

Ubiquitin mediated proteolysis

  

3

  
     

9

Glycan structures - biosynthesis 1

    

3

 

3

   

4

Glycine, serine and threonine metabolism

    

3

     

6

  1. The number in each cell represents the number of differential genes involved in the corresponding pathway. (Note: the top areas designate up-regulated genes, while the underlined (bold) one (bottom) signify down-regulated genes.)