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Table 2 Pathways significantly enriched by differentially expressed genes regulated by LH (p-value < 0.5)

From: Regulation of gene expression in ovarian cancer cells by luteinizing hormone receptor expression and activation

21 pathways uniquely involved in the up-regulated genes
Pathway (up-regulated genes involved) LHR+ LH1 LH4 LH8 LH20
Gap junction 3     5
Melanogenesis   3 5 4 5
Toll-like receptor signaling pathway   3    8
Epithelial cell signaling in Helicobacter pylori infection   3 4   3
VEGF signaling pathway    4   4
Adherens junction    5 3 3
B cell receptor signaling pathway    3   6
Adipocytokine signaling pathway    3   4
Hedgehog signaling pathway    3   
Basal cell carcinoma    3   
Cell adhesion molecules (CAMs)      3
Long-term potentiation      3
Glutathione metabolism      5
Long-term depression      4
Androgen and estrogen metabolism      4
Dorso-ventral axis formation      3
mTOR signaling pathway      3
Metabolism of xenobiotics by cytochrome P450      5
Arachidonic acid metabolism      3
Fc epsilon RI signaling pathway      6
GnRH signaling pathway      3
22 pathways uniquely involved in the down-regulated genes
Pathway (down-regulated genes involved) LHR+ LH1 LH4 LH8 LH20
Cell cycle 3   11 3 14
p53 signaling pathway 3     10
Complement and coagulation cascades 7     4
Pyrimidine metabolism      8
Alanine and aspartate metabolism      5
Urea cycle and metabolism of amino groups      6
Valine, leucine and isoleucine degradation      4
Propanoate metabolism      3
Neurodegenerative Diseases      3
Pyruvate metabolism      3
Alkaloid biosynthesis II      3
Glycerolipid metabolism      3
Carbon fixation      3
SNARE interactions in vesicular transport      3
beta-Alanine metabolism      4
Arginine and proline metabolism      4
Methionine metabolism      3
Selenoamino acid metabolism      3
Aminoacyl-tRNA biosynthesis      4
Phenylalanine metabolism      5
Glutamate metabolism      3
Basal transcription factors      3
34 pathways involved in both up- and down-regulated genes
Pathway (both up-/down-regulated genes involved) LHR+ LH1 LH4 LH8 LH20
MAPK signaling pathway 4 8 9 6 15
  3   3   12
Apoptosis      7
  4     6
Focal adhesion   3 6 4 21
  12     9
Regulation of actin cytoskeleton 3 3 5   16
  3   3   7
TGF-beta signaling pathway   4 7 4 7
  3     4
Cell Communication      11
  13     
ECM-receptor interaction      15
  10     
Jak-STAT signaling pathway   4 6   8
     3 4
Tight junction    3   4
      4
ErbB signaling pathway    3   5
  4     4
Wnt signaling pathway    4   
      7
PPAR signaling pathway      3
      3
Purine metabolism 3   3 3 4
      8
Cytokine-cytokine receptor interaction   9 13 5 12
  8   3   8
Axon guidance    6 3 11
  4     6
Prostate cancer   3 5 3 8
      5
Hematopoietic cell lineage    5 6 7
  3     
Natural killer cell mediated cytotoxicity    4   6
  4     
Neuroactive ligand-receptor interaction    3   3
  6     3
Calcium signaling pathway 3    3 6
  4     7
Insulin signaling pathway    4   5
      6
Glycerophospholipid metabolism    4   5
      3
Complement and coagulation cascades    3   7
  7     4
Tryptophan metabolism    3   5
      4
T cell receptor signaling pathway    3   6
      3
Starch and sucrose metabolism      3
  4     3
Leukocyte transendothelial migration      11
  5     4
Nitrogen metabolism      6
      3
Phosphatidylinositol signaling system      3
      3
Tyrosine metabolism      3
      6
Histidine metabolism      3
      4
Ubiquitin mediated proteolysis    3   
      9
Glycan structures - biosynthesis 1      3
  3     4
Glycine, serine and threonine metabolism      3
      6
  1. The number in each cell represents the number of differential genes involved in the corresponding pathway. (Note: the top areas designate up-regulated genes, while the underlined (bold) one (bottom) signify down-regulated genes.)