21 pathways uniquely involved in the up-regulated genes | |||||
---|---|---|---|---|---|
Pathway (up-regulated genes involved) | LHR+ | LH1 | LH4 | LH8 | LH20 |
Gap junction | 3 | Â | Â | Â | 5 |
Melanogenesis | Â | 3 | 5 | 4 | 5 |
Toll-like receptor signaling pathway | Â | 3 | Â | Â | 8 |
Epithelial cell signaling in Helicobacter pylori infection | Â | 3 | 4 | Â | 3 |
VEGF signaling pathway | Â | Â | 4 | Â | 4 |
Adherens junction | Â | Â | 5 | 3 | 3 |
B cell receptor signaling pathway | Â | Â | 3 | Â | 6 |
Adipocytokine signaling pathway | Â | Â | 3 | Â | 4 |
Hedgehog signaling pathway | Â | Â | 3 | Â | Â |
Basal cell carcinoma | Â | Â | 3 | Â | Â |
Cell adhesion molecules (CAMs) | Â | Â | Â | Â | 3 |
Long-term potentiation | Â | Â | Â | Â | 3 |
Glutathione metabolism | Â | Â | Â | Â | 5 |
Long-term depression | Â | Â | Â | Â | 4 |
Androgen and estrogen metabolism | Â | Â | Â | Â | 4 |
Dorso-ventral axis formation | Â | Â | Â | Â | 3 |
mTOR signaling pathway | Â | Â | Â | Â | 3 |
Metabolism of xenobiotics by cytochrome P450 | Â | Â | Â | Â | 5 |
Arachidonic acid metabolism | Â | Â | Â | Â | 3 |
Fc epsilon RI signaling pathway | Â | Â | Â | Â | 6 |
GnRH signaling pathway | Â | Â | Â | Â | 3 |
22 pathways uniquely involved in the down-regulated genes | |||||
Pathway (down-regulated genes involved) | LHR+ | LH1 | LH4 | LH8 | LH20 |
Cell cycle | 3 | Â | 11 | 3 | 14 |
p53 signaling pathway | 3 | Â | Â | Â | 10 |
Complement and coagulation cascades | 7 | Â | Â | Â | 4 |
Pyrimidine metabolism | Â | Â | Â | Â | 8 |
Alanine and aspartate metabolism | Â | Â | Â | Â | 5 |
Urea cycle and metabolism of amino groups | Â | Â | Â | Â | 6 |
Valine, leucine and isoleucine degradation | Â | Â | Â | Â | 4 |
Propanoate metabolism | Â | Â | Â | Â | 3 |
Neurodegenerative Diseases | Â | Â | Â | Â | 3 |
Pyruvate metabolism | Â | Â | Â | Â | 3 |
Alkaloid biosynthesis II | Â | Â | Â | Â | 3 |
Glycerolipid metabolism | Â | Â | Â | Â | 3 |
Carbon fixation | Â | Â | Â | Â | 3 |
SNARE interactions in vesicular transport | Â | Â | Â | Â | 3 |
beta-Alanine metabolism | Â | Â | Â | Â | 4 |
Arginine and proline metabolism | Â | Â | Â | Â | 4 |
Methionine metabolism | Â | Â | Â | Â | 3 |
Selenoamino acid metabolism | Â | Â | Â | Â | 3 |
Aminoacyl-tRNA biosynthesis | Â | Â | Â | Â | 4 |
Phenylalanine metabolism | Â | Â | Â | Â | 5 |
Glutamate metabolism | Â | Â | Â | Â | 3 |
Basal transcription factors | Â | Â | Â | Â | 3 |
34 pathways involved in both up- and down-regulated genes | |||||
Pathway (both up-/down-regulated genes involved) | LHR+ | LH1 | LH4 | LH8 | LH20 |
MAPK signaling pathway | 4 | 8 | 9 | 6 | 15 |
 | 3 |  | 3 |  | 12 |
Apoptosis | Â | Â | Â | Â | 7 |
 | 4 |  |  |  | 6 |
Focal adhesion | Â | 3 | 6 | 4 | 21 |
 | 12 |  |  |  | 9 |
Regulation of actin cytoskeleton | 3 | 3 | 5 | Â | 16 |
 | 3 |  | 3 |  | 7 |
TGF-beta signaling pathway | Â | 4 | 7 | 4 | 7 |
 | 3 |  |  |  | 4 |
Cell Communication | Â | Â | Â | Â | 11 |
 | 13 |  |  |  |  |
ECM-receptor interaction | Â | Â | Â | Â | 15 |
 | 10 |  |  |  |  |
Jak-STAT signaling pathway | Â | 4 | 6 | Â | 8 |
 |  |  |  | 3 | 4 |
Tight junction | Â | Â | 3 | Â | 4 |
 |  |  |  |  | 4 |
ErbB signaling pathway | Â | Â | 3 | Â | 5 |
 | 4 |  |  |  | 4 |
Wnt signaling pathway | Â | Â | 4 | Â | Â |
 |  |  |  |  | 7 |
PPAR signaling pathway | Â | Â | Â | Â | 3 |
 |  |  |  |  | 3 |
Purine metabolism | 3 | Â | 3 | 3 | 4 |
 |  |  |  |  | 8 |
Cytokine-cytokine receptor interaction | Â | 9 | 13 | 5 | 12 |
 | 8 |  | 3 |  | 8 |
Axon guidance | Â | Â | 6 | 3 | 11 |
 | 4 |  |  |  | 6 |
Prostate cancer | Â | 3 | 5 | 3 | 8 |
 |  |  |  |  | 5 |
Hematopoietic cell lineage | Â | Â | 5 | 6 | 7 |
 | 3 |  |  |  |  |
Natural killer cell mediated cytotoxicity | Â | Â | 4 | Â | 6 |
 | 4 |  |  |  |  |
Neuroactive ligand-receptor interaction | Â | Â | 3 | Â | 3 |
 | 6 |  |  |  | 3 |
Calcium signaling pathway | 3 | Â | Â | 3 | 6 |
 | 4 |  |  |  | 7 |
Insulin signaling pathway | Â | Â | 4 | Â | 5 |
 |  |  |  |  | 6 |
Glycerophospholipid metabolism | Â | Â | 4 | Â | 5 |
 |  |  |  |  | 3 |
Complement and coagulation cascades | Â | Â | 3 | Â | 7 |
 | 7 |  |  |  | 4 |
Tryptophan metabolism | Â | Â | 3 | Â | 5 |
 |  |  |  |  | 4 |
T cell receptor signaling pathway | Â | Â | 3 | Â | 6 |
 |  |  |  |  | 3 |
Starch and sucrose metabolism | Â | Â | Â | Â | 3 |
 | 4 |  |  |  | 3 |
Leukocyte transendothelial migration | Â | Â | Â | Â | 11 |
 | 5 |  |  |  | 4 |
Nitrogen metabolism | Â | Â | Â | Â | 6 |
 |  |  |  |  | 3 |
Phosphatidylinositol signaling system | Â | Â | Â | Â | 3 |
 |  |  |  |  | 3 |
Tyrosine metabolism | Â | Â | Â | Â | 3 |
 |  |  |  |  | 6 |
Histidine metabolism | Â | Â | Â | Â | 3 |
 |  |  |  |  | 4 |
Ubiquitin mediated proteolysis | Â | Â | 3 | Â | Â |
 |  |  |  |  | 9 |
Glycan structures - biosynthesis 1 | Â | Â | Â | Â | 3 |
 | 3 |  |  |  | 4 |
Glycine, serine and threonine metabolism | Â | Â | Â | Â | 3 |
 |  |  |  |  | 6 |