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Table 1 12 gene clusters identified from the differentially expressed genes

From: Regulation of gene expression in ovarian cancer cells by luteinizing hormone receptor expression and activation

Categories

Clusters

LHR-,LHR+,1h,4h,8h, 20h

#. of genes

GO(s) enriched

Pathways enriched

 

1

144

extracellular matrix structural constituent

platelet-derived growth factor alpha-receptor activity

regulation of vesicle fusion

hydroxyacid-oxoacid transhydrogenase activity

TCR

EGFR1

LH(↑)/LHR(↑)

2

157

negative regulation of apoptosis

leukocyte differentiation

carboxylic acid metabolic process

EGFR1

TGFBR

ID

KitReceptor

 

3

152

multicellular organismal development

cell proliferation

cyclic-nucleotide phosphodiesterase activity

regulation of transcription, DNA-dependent

cell-cell signaling

Hematopoietic cell lineage

LH(-)/LHR(↑)

4

205

nervous system development

neurogenesis

notch binding

calcium ion binding

cell morphogenesis

NOTCH

 

5

157

response to external stimulus

positive regulation of cellular metabolic process

AndrogenReceptor

EGFR1

LH(↓)/LHR(↑)

6

270

cadmium ion binding

transcription

spermidine biosynthetic process

regulation of RNA metabolic process

MT-HeavyMetal-Pathway

TCR

IL4

TNF alpha/NF-kB

 

7

167

neutrophil chemotaxis

positive regulation of heart rate

calcium-mediated signaling

leukocyte chemotaxis

regulation of cell migration

IL-7

ID

LH(↑)/LHR(↓)

8

145

extracellular region

collagen fibril organization

complement component C3b binding

fibrillar collagen

inflammatory response

response to external stimulus

protein digestion

IL-7

Wnt

 

9

261

amylase activity

calcium ion binding

homophilic cell adhesion

synaptogenesis

IL-7

EGFR1

LH(-)/LHR(↓)

10

288

proteinaceous extracellular matrix

polysaccharide binding

glycosaminoglycan binding

regulation of defense response

G-protein signaling, coupled to IP3 second messenger

enzyme inhibitor activity

Wnt

EGFR1

LH(↓)/LHR(↓)

11

71

regulation of aldosterone metabolic process

regulation of hormone metabolic process

auditory receptor cell differentiation

epidermis development

growth factor activity

NOTCH

TGFBR

 

12

191

cell cycle phase

mitosis

microtubule cytoskeleton

BCR

  1. Plots in the 2nd column represent the expression pattern of six conditions (SKOV-3 control, i.e. mock-transfected (LHR-), LHR expression but with no added LH, and incubation of the LHR+ cells with LH for 1h, 4h, 8h, and 20h) "↑" and "↓" denote responses of up-regulation and down-regulation, respectively and "-" denotes no alteration of gene expression.