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Table 1 12 gene clusters identified from the differentially expressed genes

From: Regulation of gene expression in ovarian cancer cells by luteinizing hormone receptor expression and activation

Categories Clusters
LHR-,LHR+,1h,4h,8h, 20h
#. of genes GO(s) enriched Pathways enriched
  1 144 extracellular matrix structural constituent
platelet-derived growth factor alpha-receptor activity
regulation of vesicle fusion
hydroxyacid-oxoacid transhydrogenase activity
TCR
EGFR1
LH(↑)/LHR(↑) 2 157 negative regulation of apoptosis
leukocyte differentiation
carboxylic acid metabolic process
EGFR1
TGFBR
ID
KitReceptor
  3 152 multicellular organismal development
cell proliferation
cyclic-nucleotide phosphodiesterase activity
regulation of transcription, DNA-dependent
cell-cell signaling
Hematopoietic cell lineage
LH(-)/LHR(↑) 4 205 nervous system development
neurogenesis
notch binding
calcium ion binding
cell morphogenesis
NOTCH
  5 157 response to external stimulus
positive regulation of cellular metabolic process
AndrogenReceptor
EGFR1
LH(↓)/LHR(↑) 6 270 cadmium ion binding
transcription
spermidine biosynthetic process
regulation of RNA metabolic process
MT-HeavyMetal-Pathway
TCR
IL4
TNF alpha/NF-kB
  7 167 neutrophil chemotaxis
positive regulation of heart rate
calcium-mediated signaling
leukocyte chemotaxis
regulation of cell migration
IL-7
ID
LH(↑)/LHR(↓) 8 145 extracellular region
collagen fibril organization
complement component C3b binding
fibrillar collagen
inflammatory response
response to external stimulus
protein digestion
IL-7
Wnt
  9 261 amylase activity
calcium ion binding
homophilic cell adhesion
synaptogenesis
IL-7
EGFR1
LH(-)/LHR(↓) 10 288 proteinaceous extracellular matrix
polysaccharide binding
glycosaminoglycan binding
regulation of defense response
G-protein signaling, coupled to IP3 second messenger
enzyme inhibitor activity
Wnt
EGFR1
LH(↓)/LHR(↓) 11 71 regulation of aldosterone metabolic process
regulation of hormone metabolic process
auditory receptor cell differentiation
epidermis development
growth factor activity
NOTCH
TGFBR
  12 191 cell cycle phase
mitosis
microtubule cytoskeleton
BCR
  1. Plots in the 2nd column represent the expression pattern of six conditions (SKOV-3 control, i.e. mock-transfected (LHR-), LHR expression but with no added LH, and incubation of the LHR+ cells with LH for 1h, 4h, 8h, and 20h) "↑" and "↓" denote responses of up-regulation and down-regulation, respectively and "-" denotes no alteration of gene expression.