In vitro effects of pazopanib on hepatoma cells and endothelial cells. The effects of pazopanib on the in vitro proliferation of various human liver cancer cells, human umbilical vein endothelial cells (HUVEC) and tumor-derived endothelial cells (TEC) at various concentrations (A), and on the apoptosis (B) and migration and invasion of 3 liver cell lines (C) at the concentration of 25 μg/mL. Tubule formation (D) and migration of HUVEC (E) were inhibited by pazopanib in a dose-dependent manner. Each experiment was repeated at least three times. Results of a representative study. Bars, SD; asterisks, P < 0.05 as compared with control.