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Table 3 Relationship between mutagen sensitivity and polymorphisms in BRCA1 185delAG and 5382insC mutations carriers who are unrelated

From: Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk

  

Genotype

Low

 

High

 

Fisher's p

185delAG

  

n = 8

%

n = 17

%

 
 

E1038G

TT

0

0

0

0

 
  

CT

3

20.0%

8

53.3%

 
  

CC

3

20.0%

2

13.3%

0.25

 

D693N

CC

4

28.6%

8

57.1%

 
  

CT

0

0.0%

2

14.3%

>0.99

 

Q356R

TT

5

17.9%

7

25.0%

 
  

CT

1

3.6%

1

3.6%

0.45

 

Rad51

GG

8

32.0%

10

40.0%

 
  

CG/CC

0

0.0%

7

28.0%

0.06

   

Low

 

High

 

Fisher's p

5382insC

  

n = 3

%

n = 8

%

 
 

E1038G

TT

2

28.6%

3

42.9%

 
  

CT/CC

0

0.0%

2

28.6%

>0.99

 

D693N

CC

2

28.6%

4

57.1%

 
  

CT

0

0.0%

1

14.3%

0.73