Figure 6

Intensity of VEGF staining of cancer cells from irbesartan sensitive (Irb-sensitive; AT1R ^LOW ) and insensitive (Irb-insensitive; AT1R ^HI ) tumours either treated with irbesartan (IRB) or untreated. (A). Counts of high VEGF-expressing infiltrating cells per tumour area (measured at 200x magnification) (B). n = 5 or 6 for each group except for AT1R^LOW tumours which, because of the reduced tumour load, had additional samples (n of 10). Between 10 and 30 images were taken from each mouse across 1 to 5 tumours (dependent on tumour load). Representative images showing both the cancer-cell VEGF staining intensity and the high-staining infiltrating cells are shown to the right. Significant P values between 0.01 and 0.05 are shown with an *, those less than 0.01 are shown with **. Data for A are shown as a box plot to illustrate changes in the median values and range while data for B are presented as mean ± S.E.M.