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Table 1 Evaluation of cytokine levels in BAL of mice 4 months post-XRT.

From: Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice

Treatment
Groups
IL-1β IL-4 IL-6 IL-12
(p40/p70)
IL-17 KC MIG MIP-1α VEGF
0%FS 26.7 ± 8.3 28.6 ± 6.3 21.0 ± 5.9 19.2 ± 3.1 0.6 ± 0.2 658.6 ± 39.3 15.3 ± 2.5 25.4 ± 7.8 26.6 ± 4.6
0%FS + XRT 12.1 ± 2.7 17.4 ± 1.0 66.0 ± 42.5 88.1 ± 18.2 0.4 ± 0.1 173.0 ± 47.0 11.4 ± 4.2 18.5 ± 3.7 43.9 ± 4.5
10%FS 14.4 ± 5.1 20.4 ± 2.3 16.6 ± 2.0 12.9 ± 1.3 0.4 ± 0.1 730.7 ± 58.4 14.6 ± 4.4 16.5 ± 3.0 21.1 ± 2.9#
10%FS + XRT (0 Day) 12.4 ± 0.8 18.2 ± 0.3 20.4 ± 1.1$ 51.1 ± 13.3$ 0.6 ± 0.1 521.0 ± 165.0* 20.9 ± 4.9 13.3 ± 1.5 21.4 ± 3.8#
10%FS + XRT (-3 wks) 14.7 ± 1.5 17.9 ± 0.6 28.0 ± 6.4 54.2 ± 13.6* 0.9 ± 0.3* 396.0 ± 49.3 14.8 ± 2.8 15.7 ± 1.6 16.9 ± 3.4#
10%FS + XRT (+2 wks) 13.1 ± 2.9 15.9 ± 1.0 16.6 ± 1.7* 43.2 ± 7.9* 0.3 ± 0.1§§ 380.5 ± 162.7 7.2 ± 2.0 14.5 ± 1.7 13.4 ± 1.3#
10%FS + XRT (+4 wks) 7.4 ± 1.0 16.6 ± 0.6 13.0 ± 1.8* 16.2 ± 1.2# § 0.1 ± 0.0§§ 444.0 ± 66.8 8.8 ± 1.6 10.0 ± 1.2 6.8 ± 2.2#
10%FS + XRT (+6 wks) 7.7 ± 1.2 16.5 ± 0.9 15.3 ± 1.7$ 26.8 ± 7.1# 0.2 ± 0.0§§ 264.7 ± 150.7 9.0 ± 4.8 10.0 ± 2.1 11.7 ± 1.8#
  1. Mice were fed with 0% or 10%FS diet prior (-3 weeks) or post (+2, +4, +6 weeks) X-ray radiation therapy (XRT) and sacrificed after 4 months. Lungs were lavaged and cytokine levels in BAL were measured. Data is represented mean ± SEM of two independent experiments (n = 15 and 25 mice in non-irradiated and irradiated groups, respectively). Values are mean ± SEM of two independent experiments. n = 15 and 25 in non irradiated and irradiated groups respectively.
  2. $ p ≤ 0.05, * p ≤ 0.01, # p ≤ 0.0005, for 0%FS irradiated vs. 10%FS irradiated groups.
  3. §p ≤ 0.05, §§ p ≤ 0.01 for 10%FS given preventively to XRT Vs 10%FS started therapeutically post-XRT.