Figure 8

Determination of fibrotic changes in mouse lungs 4 months post-XRT. Panel A: Evaluation of OH-Proline content in lungs of irradiated (13.5 Gy, XRT) mice. Mice were fed with 0% or 10%FS diet prior (-3 weeks) or post (+2, +4, +6 weeks) XRT. Lungs were harvested after 4 months and OH-Proline assay was performed. *p ≤ 0.005 for irradiated 0%FS vs. irradiated 10%FS. Panel B: Fibrotic Index range = 0 - 4). Data is represented mean ± SEM of two independent experiments (n = 15-25 mice per group). The white, black, gray and hatched bars represent untreated control, 0%FS + XRT, 10%FS and 10%FS + XRT groups respectively. *p ≤ 0.005 for irradiated 0%FS vs. irradiated 10%FS. *p ≤ 0.005 for irradiated 0%FS vs. irradiated 10%FS.