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Table 2 Correlation between the expression of pFOXO1 and that of angiogenesis-related proteins in tumor cells in gastric cancer

From: Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules

 

pFOXO1

 
 

Positive (%)

Negative (%)

P

pFOXO1

   

HIF-1α

   

   Positive

64 (96)

3 (4)

0.003*

   Negative

133 (80)

34 (20)

 

VEGF

   

   Positive

87 (93)

7 (7)

0.004*

   Negative

110 (79)

30 (21)

 

pAKT

   

   Positive

169 (90)

18 (10)

< 0.001*

   Negative

28 (60)

19 (40)

 

NF-κB

   

   Positive

38 (95)

2 (5)

0.040*

   Negative

159 (82)

35 (18)

 

pSTAT3

   

   Positive

49 (89)

6 (11)

0.255

   Negative

148 (83)

31 (17)

 

β-catenin

   

   Positive

38 (86)

6 (14)

0.661

   Negative

159 (84)

31 (16)

 
  1. Abbreviations: pFOXO1, phosphorylated Forkhead in rhabdomyosarcoma (cytoplasmic staining);
  2. HIF-1α, hypoxia inducible factor-1α (nuclear staining); VEGF, vessel endothelial growth factor (cytoplasmic staining); pAKT, phosphorylated protein kinase B (cytoplasmic and nuclear staining);
  3. NF-κB, nuclear factor-κB (nuclear staining); pSTAT3, phosphorylated signal transducer and activator of transcription 3 (nuclear staining); β-catenin (nuclear staining)
  4. * Considered to be statistically significant.
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BMC Cancer

ISSN: 1471-2407

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