Figure 3

RKIP and pRKIP expression levels as a function of tumor progression. Columns, means, bars, SE. (A) Expression levels are represented by the integrated intensity of RKIP expression in the cytoplasm of relevant cells as described in Materials and Methods. Note, there is no statistically significant difference between any of the expression levels shown. (B) Expression levels are represented by the integrated intensity of pRKIP expression in the cytoplasm of relevant cells as described in Materials and Methods. Note, there was a statistically significant group difference of pRKIP expression (P < 0.0001) with a slight decrease in expression in metastatic cells compared to morphologically normal bronchial epithelium and primary NSCLC lesion.