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Figure 5 | BMC Cancer

Figure 5

From: Gβγ subunits inhibit Epac-induced melanoma cell migration

Figure 5

Ca 2+ signal cross talk between Epac and Gβγ. Activation of GPCR releases two signaling molecules, Gα and Gβγ. Gα activates cAMP production, leading to Ca 2+ release from IP3 receptor in the ER via Epac/PLC/IP3 pathway. Ca 2+ release from IP3 receptor induces cell migration. On the other hand, Gβγ stimulates Ca 2+ influx from the extracellular space, leading to activation of calmodulin and the following inactivation of IP3 receptor. Finally, Gβγ inhibits Epac-induced Ca 2+ release from the ER, leading to inhibition of cell migration.

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