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Figure 6 | BMC Cancer

Figure 6

From: Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma

Figure 6

The combinations of cladribine and S3I-201 significantly induce apoptosis in MM cells. MM cells were untreated or treated with either S3I-201 (5 μmol/L), or cladribine (2 μmol/L for U266, 1 μmol/L for RPMI8226, 0.2 μmol/L for MM1.S) alone, or the combinations of S3I-201 and cladribine for 24 hrs. A, Cells were collected and subjected to western blot analyses with specific antibodies directed against caspase-3 (Casp-3), caspase-8 (Casp-8), PARP, or β-actin. B, Cells were collected and subjected to a specific apoptotic-ELISA. Bars, SD. P values vs single agent.

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