Skip to main content
Figure 4 | BMC Cancer

Figure 4

From: P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the Aurora-B Kinase Inhibitor barasertib-hQPA

Figure 4

Specificity of barasertib-hQPA in AML cell lines in combination with ABC transporter modulators. A, Effect of 24 hours barasertib-hQPA exposure +/- 2.5 μg/ml CSA on pHH3 expression in OCI-AML3, OCI-AML3DNR and KG-1a cells (*p = 0.145/**p = 0.145) (analysed using paired samples t-test), +95% confidence interval) (i). Effect of 72 hours barasertib-hQPA exposure +/-2.5 μg/ml CSA on viable cell count (ii). B, Effect of 24 hours barasertib-hQPA exposure +/- 5 μM FTC on pHH3 expression in OCI-AML3 and OCI-AML6.2 cells (***p = 0.021) (i). Effect of 72 hours barasertib-hQPA exposure +/- 5 μM on viable cell count (ii). Columns/lines, mean of three experiments; bars, SD.

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us