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Figure 1 | BMC Cancer

Figure 1

From: P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the Aurora-B Kinase Inhibitor barasertib-hQPA

Figure 1

Expression of ABC transporters in AML cell lines. A, Pgp function was measured using R123 accumulation and Cyclosporine A as a positive control modulator. BCRP was measured similarly with BODIPY-prazosin accumulation and Fumitremorgin C as the modulator. (*p = 0.039/**p = 0.015/***p = 0.002) (analysed using paired samples t-test), +95% confidence interval). B, Pgp protein expression was determined using the MRK-16 monoclonal antibody (*p = 0.003/**p = 0.006). C, MRP function was measured using Calcein-AM accumulation and MK-571 as a modulator (*p = 0.358/**p = 0.004). Columns, mean of three experiments; bars, SD.

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