Figure 6From: Limited importance of the dominant-negative effect of TP53missense mutations Two proposed hypotheses (generation and selection). (A) In vitro generation of 17p LOH or in vitro occurring selection of small subpopulation of cells without wild type TP53 allele. (B) In vitro mutation of allele showing in vivo normal sequence or in vitro occurring selection of small subpopulation of cells with 2 mutated TP53 alleles.Back to article page