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Table 6 Significant alterations in expression of previously reported important transcription factors in tumors of high intrinsic COX-2 expression

From: COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

Gene Product FC 1.5 FC 2.0 FC 3.0 Referencea
TFAP2C AP-2γ - - [12]
TFAP2E AP-2ε - - - [12]
ATF1 ATF1 - - - [13]
ATF2 ATF2/CREB2 - - - [13]
ATF3 ATF3/AP1 - - [13]
BATF B-ATF - - - [13]
CREBBP CBP/p300 co-activator - - - [12]
CDX2 CDX2 - - [29]
CEBPA C/EBP-α - - - [13]
CEBPB C/EBP-β - - - [13]
CEBPD C/EBP-δ - [13]
CREB5 CRE-BPA - - - [13]
CREB1 CREB - - - [13]
ELK1 Elk-1 - - [13]
FOS c-Fos/AP1 - - [12]
FOSB Fos-B/AP1 [12]
FOSL1 Fra-1/AP1 - - - [12]
FOSL2 Fra-2/AP1 - - - [12]
DNAJC12 JDP1 - - - [12]
JDP2 JDP2 - - [12]
JUN Jun/AP1 - - - [12]
JUNB JunB/AP1 - - - [12]
JUND JunD/AP1 - - [12]
MAF c-Maf/AP1 - [12]
NFATC1 NFATc1/NFAT2 - - - [12]
NFATC4 NFAT3 - - - [12]
NFATC3 NFAT4 - - - [12]
NFAT5 NFAT5 - - - [12]
NFKB1 NF-κB, p105/p50 - - - [12, 13]
NFKB2 NF-κB, p100 - - - [12, 13]
RELA NF-κB, RelA (p65) - - - [12, 13]
RELB NF-κB, RelB - - - [12, 13]
REL NF-κB, c-Rel - - - [12, 13]
NFKBIA NF-κB, IκBα - [12, 13]
NFKBIB NF-κB, IκBβ - - - [12, 13]
NFKBIE NF-κB, IκBε - - - [12, 13]
CHUK NF-κB, IKK-α - - - [12, 13]
IKBKB NF-κB, IKK-β - - - [12, 13]
IKBKG NF-κB, IKK-γ - - - [12, 13]
TP53 p53 - [30]
ETV4 PEA3 - - [13]
PPARA PPARα - - - [12]
PPARD PPARβ/δ - - - [12]
PPARG PPARγ - - - [12]
SP1 SP-1 - - - [12]
TBP TATA-binding protein - - - [12]
TCF4 TCF4 - [13]
  1. AP-2α, AP-2β, AP-2δ, NFAT1 and Retinoic acid receptor were also tested, but no expression were found.
  2. increased expression; decreased expression; FC is log2 fold changes
  3. a published report with emphasis on transcription factor in regulation of COX-2 gene.