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Table 5 Genes listed according to the magnitude of most altered expression in normal mucosa from patients with tumors of high intrinsic COX-2 expression

From: COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

Gene ↑/↓ FC Function Gene Symbol (GeneID)
Pancreatic derived factor (PANDER) 79 Cytokine, induces apoptosis of alpha and beta cells, implicated in diabetes FAM3B (54097)
Regenerating islet-derived 1 α 40 Secreted by the exocrine pancreas, associated with islet cell regeneration and diabetogenesis REG1A (5967)
Ribosomal protein S4, Y-linked 2 40 Translation RPS4Y2 (140032)
Serpin peptidase inhibitor, ovalbumin 35 Cytoprotective, cell survival factor, monocyte regulation, potential cancer marker (elevated in plasma) SERPINB2 (5055)
Nitric oxide synthase 2, inducible 19 reactive free radical, biologic mediator in several processes, incl. neurotransmission, antimicrobial and antitumoral activities NOS2A (4843)
Pentraxin-related gene 16 Immune response, inflammation, rapidly induced by IL-1β PTX3 (5806)
Regenerating islet-derived 1 β 16 highly similar to REG1A protein REG1B (5968)
Hydroxy-delta-5-steroid dehydrogenase 10 Biosynthesis of steroid hormones, polymorphisms related to prostate cancer HSD3B2 (3284)
Hydroxy-delta-5-steroid dehydrogenase 10 Biosynthesis of steroid hormones, diagnostic trophoblastic marker HSD3B1 (3283)
ADAM metallopeptidase 10 cleavage of proteoglycans, control of organ shape during development, and inhibition of angiogenesis ADAMTS9 (56999)
Unknown 15 unknown ENST00000343
6-phosphofructo-2-kinase 13 Produce fructose 2,6-P(2), involved in Warburg effect PFKFB3 (5209)
hemoglobin, γ A 8 Normally expressed in the fetal liver, spleen and bone marrow HBG1 (3047)
matrix metallopeptidase 7 8 Breakdown of extracellular matrix, metastasis MMP7 (4316)
Fc receptor-like 4 7 Immune regulation FCRL4 (83417)
Chemokine receptor 5 6 B cell migration and localization BLR1 (643)
Fibroblast growth factor 5 6 Mitogenic and cell survival activities, involved in a variety of biological processes, incl. cell growth, morphogenesis, tissue repair, tumor growth and invasion, oncogene FGF5 (2250)
Family with sequence similarity 129, member C 6 B-cell novel protein, BCNP1 completely unknown protein with 3 predicted transmembrane domains FAM129C (199786)
selectin L 6 Leukocyte-endothelial cell interactions SELL (6402)
Zinc finger protein 5 DNA binding ZNF683 (257101)
  1. increased expression
  2. decreased expression