Table 5 Genes listed according to the magnitude of most altered expression in normal mucosa from patients with tumors of high intrinsic COX-2 expression

Pancreatic derived factor (PANDER)

79

Cytokine, induces apoptosis of alpha and beta cells, implicated in diabetes

FAM3B (54097)

Regenerating islet-derived 1 α

40

Secreted by the exocrine pancreas, associated with islet cell regeneration and diabetogenesis

REG1A (5967)

Ribosomal protein S4, Y-linked 2

40

Translation

RPS4Y2 (140032)

Serpin peptidase inhibitor, ovalbumin

35

Cytoprotective, cell survival factor, monocyte regulation, potential cancer marker (elevated in plasma)

SERPINB2 (5055)

Nitric oxide synthase 2, inducible

19

reactive free radical, biologic mediator in several processes, incl. neurotransmission, antimicrobial and antitumoral activities

NOS2A (4843)

Pentraxin-related gene

16

Immune response, inflammation, rapidly induced by IL-1β

PTX3 (5806)

Regenerating islet-derived 1 β

16

highly similar to REG1A protein

REG1B (5968)

Hydroxy-delta-5-steroid dehydrogenase

10

Biosynthesis of steroid hormones, polymorphisms related to prostate cancer

HSD3B2 (3284)

Hydroxy-delta-5-steroid dehydrogenase

10

Biosynthesis of steroid hormones, diagnostic trophoblastic marker

HSD3B1 (3283)

ADAM metallopeptidase

10

cleavage of proteoglycans, control of organ shape during development, and inhibition of angiogenesis

ADAMTS9 (56999)

Unknown

15

unknown

ENST00000343

6-phosphofructo-2-kinase

13

Produce fructose 2,6-P(2), involved in Warburg effect

PFKFB3 (5209)

hemoglobin, γ A

8

Normally expressed in the fetal liver, spleen and bone marrow

HBG1 (3047)

matrix metallopeptidase 7

8

Breakdown of extracellular matrix, metastasis

MMP7 (4316)

Fc receptor-like 4

7

Immune regulation

FCRL4 (83417)

Chemokine receptor 5

6

B cell migration and localization

BLR1 (643)

Fibroblast growth factor 5

6

Mitogenic and cell survival activities, involved in a variety of biological processes, incl. cell growth, morphogenesis, tissue repair, tumor growth and invasion, oncogene

FGF5 (2250)

Family with sequence similarity 129, member C

6

B-cell novel protein, BCNP1 completely unknown protein with 3 predicted transmembrane domains

FAM129C (199786)

selectin L

6

Leukocyte-endothelial cell interactions

SELL (6402)

Zinc finger protein

5

DNA binding

ZNF683 (257101)