|
Pancreatic derived factor (PANDER)
|
↑
|
79
|
Cytokine, induces apoptosis of alpha and beta cells, implicated in diabetes
|
FAM3B (54097)
|
|
Regenerating islet-derived 1 α
|
↑
|
40
|
Secreted by the exocrine pancreas, associated with islet cell regeneration and diabetogenesis
|
REG1A (5967)
|
|
Ribosomal protein S4, Y-linked 2
|
↑
|
40
|
Translation
|
RPS4Y2 (140032)
|
|
Serpin peptidase inhibitor, ovalbumin
|
↑
|
35
|
Cytoprotective, cell survival factor, monocyte regulation, potential cancer marker (elevated in plasma)
|
SERPINB2 (5055)
|
|
Nitric oxide synthase 2, inducible
|
↑
|
19
|
reactive free radical, biologic mediator in several processes, incl. neurotransmission, antimicrobial and antitumoral activities
|
NOS2A (4843)
|
|
Pentraxin-related gene
|
↑
|
16
|
Immune response, inflammation, rapidly induced by IL-1β
|
PTX3 (5806)
|
|
Regenerating islet-derived 1 β
|
↑
|
16
|
highly similar to REG1A protein
|
REG1B (5968)
|
|
Hydroxy-delta-5-steroid dehydrogenase
|
↑
|
10
|
Biosynthesis of steroid hormones, polymorphisms related to prostate cancer
|
HSD3B2 (3284)
|
|
Hydroxy-delta-5-steroid dehydrogenase
|
↑
|
10
|
Biosynthesis of steroid hormones, diagnostic trophoblastic marker
|
HSD3B1 (3283)
|
|
ADAM metallopeptidase
|
↑
|
10
|
cleavage of proteoglycans, control of organ shape during development, and inhibition of angiogenesis
|
ADAMTS9 (56999)
|
|
Unknown
|
↓
|
15
|
unknown
|
ENST00000343
|
|
6-phosphofructo-2-kinase
|
↓
|
13
|
Produce fructose 2,6-P(2), involved in Warburg effect
|
PFKFB3 (5209)
|
|
hemoglobin, γ A
|
↓
|
8
|
Normally expressed in the fetal liver, spleen and bone marrow
|
HBG1 (3047)
|
|
matrix metallopeptidase 7
|
↓
|
8
|
Breakdown of extracellular matrix, metastasis
|
MMP7 (4316)
|
|
Fc receptor-like 4
|
↓
|
7
|
Immune regulation
|
FCRL4 (83417)
|
|
Chemokine receptor 5
|
↓
|
6
|
B cell migration and localization
|
BLR1 (643)
|
|
Fibroblast growth factor 5
|
↓
|
6
|
Mitogenic and cell survival activities, involved in a variety of biological processes, incl. cell growth, morphogenesis, tissue repair, tumor growth and invasion, oncogene
|
FGF5 (2250)
|
|
Family with sequence similarity 129, member C
|
↓
|
6
|
B-cell novel protein, BCNP1 completely unknown protein with 3 predicted transmembrane domains
|
FAM129C (199786)
|
|
selectin L
|
↓
|
6
|
Leukocyte-endothelial cell interactions
|
SELL (6402)
|
|
Zinc finger protein
|
↓
|
5
|
DNA binding
|
ZNF683 (257101)
|
