Table 3 Genes listed according to the magnitude of most altered expression between tumor tissue and normal mucosa from the same patients with tumors of high intrinsic COX-2 expression
Gene | ↑/↓ | FC | Function | Gene Symbol (GeneID) |
|---|---|---|---|---|
Matrix metallopeptidase 7 | ↑ | 110 | Breakdown of extracellular matrix, metastasis | MMP7 (4316) |
Keratin 23 | ↑ | 77 | Structural integrity of epithelial cells | KRT23 (25984) |
Myosin | ↑ | 63 | Muscle, heavy polypeptide 2 | MYH2 (4620) |
Claudin 1 | ↑ | 38 | Integral membrane protein, component of tight junction strands | CLDN1 (9076) |
Actin α1, skeletal | ↑ | 36 | Cell motility, structure and integrity | ACTA1 (58) |
Forkhead box Q1 | ↑ | 34 | Transcription factor (i.e. TGF-beta2) | FOXQ1 (94234) |
Proprotein convertase subtilisin/kexin type 1 | ↑ | 22 | Regulating insulin biosynthesis, obesity, activate precursor protein, associated with carcinoid tumors | PCSK1 (5122) |
Sarcolipin | ↑ | 25 | Regulates several sarcoplasmic reticulum Ca(2+)-ATPases | SLN (6588) |
Matrix metallopeptidase 1 | ↑ | 14 | Breakdown of extracellular matrix, metastasis | MMP1 (4312) |
Myosin, cardiac, beta | ↑ | 25 | Heavy chain, also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers | MYH7 (4625) |
Hydroxy-δ-5-steroid dehydrogenase | ↓ | 79 | Biosynthesis of steroid hormones, polymorphisms related to prostate cancer | HSD3B2 (3284) |
Hydroxy-δ-5-steroid dehydrogenase | ↓ | 30 | Biosynthesis of steroid hormones, diagnostic trophoblastic marker | HSD3B1 (3283) |
similar to 3 β-hydroxysteroid dehydrogenase | ↓ | 28 | Pseudogene | LOC391081 (391081) |
- | ↓ | 24 | unknown | CR627415 |
Butyrylcholinesterase | ↓ | 21 | Homozygoutics sustain prolonged apnea after administration of the muscle relaxant suxamethonium | BCHE (590) |
Neuronal pentraxin | ↓ | 19 | Excitatory synapse remodelling, mediate neuronal death induced by reduction in neuronal activity in mature neurons | NPTX1 (4884) |
Dipeptidyl-peptidase 6 | ↓ | 18 | Binds and alters specific voltage-gated potassium channels expression and biophysical properties | DPP6 (1804) |
ATP-binding cassette, sub-family G | ↓ | 17 | Breast cancer resistance protein, xenobiotic transporter may play a major role in multi-drug resistance | ABCG2 (9429) |
Insulin like-5 | ↓ | 17 | Relaxin/Insulin family, ligand for GPCR142 | INSL5 (10022) |
Regenerating islet-derived 1 β | ↓ | 16 | Highly similar to REG1A protein (islet cell regeneration and diabetogenesis) | REG1B (5968) |