Skip to main content

Table 3 Genes listed according to the magnitude of most altered expression between tumor tissue and normal mucosa from the same patients with tumors of high intrinsic COX-2 expression

From: COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

Gene ↑/↓ FC Function Gene Symbol (GeneID)
Matrix metallopeptidase 7 110 Breakdown of extracellular matrix, metastasis MMP7 (4316)
Keratin 23 77 Structural integrity of epithelial cells KRT23 (25984)
Myosin 63 Muscle, heavy polypeptide 2 MYH2 (4620)
Claudin 1 38 Integral membrane protein, component of tight junction strands CLDN1 (9076)
Actin α1, skeletal 36 Cell motility, structure and integrity ACTA1 (58)
Forkhead box Q1 34 Transcription factor (i.e. TGF-beta2) FOXQ1 (94234)
Proprotein convertase subtilisin/kexin type 1 22 Regulating insulin biosynthesis, obesity, activate precursor protein, associated with carcinoid tumors PCSK1 (5122)
Sarcolipin 25 Regulates several sarcoplasmic reticulum Ca(2+)-ATPases SLN (6588)
Matrix metallopeptidase 1 14 Breakdown of extracellular matrix, metastasis MMP1 (4312)
Myosin, cardiac, beta 25 Heavy chain, also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers MYH7 (4625)
Hydroxy-δ-5-steroid dehydrogenase 79 Biosynthesis of steroid hormones, polymorphisms related to prostate cancer HSD3B2 (3284)
Hydroxy-δ-5-steroid dehydrogenase 30 Biosynthesis of steroid hormones, diagnostic trophoblastic marker HSD3B1 (3283)
similar to 3 β-hydroxysteroid dehydrogenase 28 Pseudogene LOC391081 (391081)
- 24 unknown CR627415
Butyrylcholinesterase 21 Homozygoutics sustain prolonged apnea after administration of the muscle relaxant suxamethonium BCHE (590)
Neuronal pentraxin 19 Excitatory synapse remodelling, mediate neuronal death induced by reduction in neuronal activity in mature neurons NPTX1 (4884)
Dipeptidyl-peptidase 6 18 Binds and alters specific voltage-gated potassium channels expression and biophysical properties DPP6 (1804)
ATP-binding cassette, sub-family G 17 Breast cancer resistance protein, xenobiotic transporter may play a major role in multi-drug resistance ABCG2 (9429)
Insulin like-5 17 Relaxin/Insulin family, ligand for GPCR142 INSL5 (10022)
Regenerating islet-derived 1 β 16 Highly similar to REG1A protein (islet cell regeneration and diabetogenesis) REG1B (5968)
  1. increased expression
  2. decreased expression